Evidence map›Paper›PMID 22064537›Full record

ArticleAntimicrobial agents and chemotherapy2012

The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U.

Lorraine A Draper, John R Tagg, Colin Hill, Paul D Cotter, R Paul Ross

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Lantibiotic resistance.Microbiology and molecular biology reviews : MMBR · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Lorraine A DraperDepartment of Microbiology, University College Cork, Cork, Ireland.
John R Tagg
Colin Hill
Paul D Cotter
R Paul Ross
University College Cork · IETeagasc - The Irish Agriculture and Food Development Authority · IEUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.

Indexed as

Anti-Bacterial AgentsBacteriocinsDNA, BacterialDrug Resistance, BacterialEscherichia coliGene ExpressionGenes, BacterialGenetic LociLactococcus lactisMolecular MimicryNisinStreptococcusAnti-Bacterial AgentsBacteriocinsDNA, BacterialNisin

Identifiers

PMID22064537
PMCPMC3256037
OpenAlexW1978221288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.