ReviewNucleus (Austin, Tex.)
Physical breakdown of the nuclear envelope is not necessary for breaking its barrier function.
Review in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Molecular and cellular dynamics of early embryonic cell divisions in Volvox carteri.The Plant cell · 2022Article
- Tell the Difference Between Mitosis and Meiosis: Interplay Between Chromosomes, Cytoskeleton, and Cell Cycle Regulation.Frontiers in cell and developmental biology · 2021Review
- Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum.Communications biology · 2020Article
- Epigenetic countermarks in mitotic chromosome condensation.Nucleus (Austin, Tex.) · 2017Review
- Virtual Nuclear Envelope Breakdown and Its Regulators in Fission Yeast Meiosis.Frontiers in cell and developmental biology · 2016Review
- Ordered kinetochore assembly in the human-pathogenic basidiomycetous yeast Cryptococcus neoformans.mBio · 2013Article
- Structural and functional studies of the 252 kDa nucleoporin ELYS reveal distinct roles for its three tethered domains.Structure (London, England : 1993) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mitosis in higher eukaryotic cells, nuclear envelope breakdown (NEBD) occurs and leads to the disassembly of the nuclear membrane and nuclear pore complexes (NPC). This brings about a mixing of nuclear and cytoplasmic macromolecules (open mitosis). On the other hand, in many fungi, mitosis occurs without NEBD (closed mitosis). In a recent study, we reported a novel phenomenon in a closed mitosis organism, Schizosaccharomyces pombe: mixing of nuclear and cytoplasmic proteins occurred in meiosis without breakdown of the nuclear membrane or disassembly of nuclear pore complexes. We designated this event virtual nuclear envelope breakdown (V-NEBD). The key event in V-NEBD is nuclear translocation of Rna1, a RanGAP1 homologue in S. pombe. This leads to collapse of the Ran-GTP gradient across the nuclear envelope (NE) and occurs coincidently with V-NEBD. Thus, the barrier function of the NE can be abated without its physical breakdown through modulation of the Ran-GTP gradient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.