ArticleTalanta2011
A novel biosensor based on serum antibody immobilization for rapid detection of viral antigens.
Article in Talanta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Evaluation of polyclonal antibodies raised in rabbits against dengue NS1 antigen.Scientific reports · 2026Article
- Biosensors for the detection of flaviviruses: A review.Synthetic and systems biotechnology · 2025Review
- Biosensors for Detection of Hepatitis B Virus: Review.Current medicinal chemistry · 2025Review
- Pathogen Detection via Impedance Spectroscopy-Based Biosensor.Sensors (Basel, Switzerland) · 2024Article
- Point-of-care detection of Japanese encephalitis virus biomarker in clinical samples using a portable smartphone-enabled electrochemical "Sensit" device.Bioengineering & translational medicine · 2023Article
- Dengue virus infection - a review of pathogenesis, vaccines, diagnosis and therapy.Virus research · 2023Review
- ACE2-based capacitance sensor for rapid native SARS-CoV-2 detection in biological fluids and its correlation with real-time PCR.Biosensors & bioelectronics · 2022Article
- The perspectives of biomarker-based electrochemical immunosensors, artificial intelligence and the Internet of Medical Things toward COVID-19 diagnosis and management.Materials today. Chemistry · 2021Review
- Electrochemical diagnostics of infectious viral diseases: Trends and challenges.Biosensors & bioelectronics · 2021Review
- The potential application of electrochemical biosensors in the COVID-19 pandemic: A perspective on the rapid diagnostics of SARS-CoV-2.Biosensors & bioelectronics · 2021Review
- Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art.Biosensors & bioelectronics · 2020Review
- Graphene functionalized field-effect transistors for ultrasensitive detection of Japanese encephalitis and Avian influenza virus.Scientific reports · 2020Article
- Label-Free Electrochemical Biosensors for the Determination ofSensors (Basel, Switzerland) · 2020Review
- Article
- Preparation and Investigation of Silver Nanoparticle⁻Antibody Bioconjugates for Electrochemical Immunoassay of Tick-Borne Encephalitis.Sensors (Basel, Switzerland) · 2019Article
- Article
- Rapid immunoglobulin M-based dengue diagnostic test using surface plasmon resonance biosensor.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we represent a label-free biosensor based on immobilization of serum antibodies for rapid detection of viral antigens. Human serum containing specific antibodies against Japanese encephalitis virus (JEV) was immobilized on a silanized surface of an interdigitated sensor via protein A/glutaraldehyde for electrical detection of JEV antigens. The effective immobilization of serum antibodies on the sensor surface was verified by Fourier transform infrared spectrometry and fluorescence microscopy. The signal of the biosensor obtained by the differential voltage converted from the change into non-Faradic impedance resulting from the specific binding of JEV antigens on the surface of the sensor. The detection analyzed indicates that the detection range of this biosensor is 1-10 μg/ml JEV antigens, with a detection limit of 0.75 μg/ml and that stable signals are measured in about 20 min. This study presents a useful biosensor with a high selectivity for rapid and simple detection of JEV antigens, and it also proposes the biosensor as a future diagnostic tool for rapid and direct detection of viral antigens in clinical samples for preliminary pathogenic screenings in the case of possible outbreaks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.