ArticleJournal of molecular and cellular cardiology2012
MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts.
Article in Journal of molecular and cellular cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Paracrine effects of mir-210-3p on angiogenesis in hypoxia-treated c-kit-positive cardiac cells.Annals of medicine · 2023Article
- Review
- Sustained cardiac programming by short-term juvenile exercise training in male rats.The Journal of physiology · 2018Article
- Article
- Involment of RAS/ERK1/2 signaling and MEF2C in miR-155-3p inhibition-triggered cardiomyocyte differentiation of embryonic stem cell.Oncotarget · 2017Article
- Possible Muscle Repair in the Human Cardiovascular System.Stem cell reviews and reports · 2017Review
- Cardiac regenerative medicine: At the crossroad of microRNA function and biotechnology.Non-coding RNA research · 2017Review
- Article
- Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2016Article
- Strategies and Challenges to Myocardial Replacement Therapy.Stem cells translational medicine · 2016Review
- The role of microRNAs in cardiac development and regenerative capacity.American journal of physiology. Heart and circulatory physiology · 2016Review
- Review
- MicroRNAs and Cardiac Regeneration.Circulation research · 2015Review
- Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3.The Journal of biological chemistry · 2015Article
- Stimulating endogenous cardiac repair.Frontiers in cell and developmental biology · 2015Review
- Update on the Pathogenic Implications and Clinical Potential of microRNAs in Cardiac Disease.BioMed research international · 2015Review
- The Role of MicroRNAs in Cardiac Stem Cells.Stem cells international · 2015Review
- Review
- MicroRNAs in myocardial ischemia: identifying new targets and tools for treating heart disease. New frontiers for miR-medicine.Cellular and molecular life sciences : CMLS · 2014Review
- Cardiac progenitor/stem cells on myocardial infarction or ischemic heart disease: what we have known from current research.Heart failure reviews · 2014Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Cardiac progenitor cells (CPCs) are multipotent cells that may offer tremendous potentials for the regeneration of injured myocardium. To expand the limited number of CPCs for effective clinical regeneration of myocardium, it is important to understand their proliferative potentials. Single-cell based assays were utilized to purify c-kit(pos) CPCs from human and mouse hearts. MicroRNA profiling identified eight differentially expressed microRNAs in CPCs from neonatal and adult hearts. Notably, the predicted protein targets were predominantly involved in cellular proliferation-related pathways. To directly test this phenotypic prediction, the developmental variance in the proliferation of CPCs was tested. Ki67 protein expression and DNA kinetics were tested in human and mouse in vivo CPCs, and doubling times were tested in primary culture of mouse CPCs. The human embryonic and mouse neonatal CPCs showed a six-fold increase in Ki67 expressing cells, a two-fold increase in the number of cells in S/G2-M phases of cell cycle, and a seven-fold increase in the doubling time in culture when compared to the corresponding adult CPCs. The over-expression of miR-17-92 increased the proliferation in adult CPCs in vivo by two-fold. In addition, the level of retinoblastoma-like 2 (Rbl2/p130) protein was two-fold higher in adult compared to neonatal-mouse CPCs. In conclusion, we demonstrate a differentially regulated cohort of microRNAs that predicts differences in cellular proliferation in CPCs during postnatal development and target microRNAs that are involved in this transition. Our study provides new insights that may enhance the utilization of adult CPCs for regenerative therapy of the injured myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.