ReviewBiochimica et biophysica acta2012
The mechanism of dynein motility: insight from crystal structures of the motor domain.
Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1.Frontiers in molecular biosciences · 2026Review
- A Comprehensive Genetic Study of Microtubule-Associated Gene Clusters for Male Infertility in a Taiwanese Cohort.International journal of molecular sciences · 2023Article
- Motility Assessment of Ram Spermatozoa.Biology · 2022Review
- Genetic Defects inFrontiers in cell and developmental biology · 2021Article
- Setting the dynein motor in motion: New insights from electron tomography.The Journal of biological chemistry · 2019Review
- A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1).Molecular biology of the cell · 2018Article
- Regulation of long-distance transport of mitochondria along microtubules.Cellular and molecular life sciences : CMLS · 2018Review
- Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Assessing heterogeneity in oligomeric AAA+ machines.Cellular and molecular life sciences : CMLS · 2017Review
- ATP Consumption of Eukaryotic Flagella Measured at a Single-Cell Level.Biophysical journal · 2015Article
- Torsins: not your typical AAA+ ATPases.Critical reviews in biochemistry and molecular biology · 2015Review
- Article
- Function and regulation of dynein in mitotic chromosome segregation.Chromosoma · 2014Review
- A structural analysis of the AAA+ domains in Saccharomyces cerevisiae cytoplasmic dynein.Journal of structural biology · 2014Article
- Slow axonemal dynein e facilitates the motility of faster dynein c.Biophysical journal · 2014Article
- Structural mechanism of the dynein power stroke.Nature cell biology · 2014Article
- Article
- The PAR polarity complex and cerebellar granule neuron migration.Advances in experimental medicine and biology · 2014Review
- Functions and mechanics of dynein motor proteins.Nature reviews. Molecular cell biology · 2013Review
- Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains.eLife · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Dynein is a large cytoskeletal motor protein that belongs to the AAA+ (ATPases associated with diverse cellular activities) superfamily. While dynein has had a rich history of cellular research, its molecular mechanism of motility remains poorly understood. Here we describe recent X-ray crystallographic studies that reveal the architecture of dynein's catalytic ring, mechanical linker element, and microtubule binding domain. This structural information has given rise to new hypotheses on how the dynein motor domain might change its conformation in order to produce motility along microtubules.
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Registered trials
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