ArticleBiochimica et biophysica acta2012
Saturation with cholesterol increases vertical order and smoothes the surface of the phosphatidylcholine bilayer: a molecular simulation study.
Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Multiscale characterization of lipid bilayer disruption induced by Methyl-β-cyclodextrin (MβCD).European biophysics journal : EBJ · 2026Article
- Preventing Age-Related Nuclear Cataract Development - Is Cholesterol the Key?Investigative ophthalmology & visual science · 2026Review
- Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens.Investigative ophthalmology & visual science · 2025Article
- Interaction of βInternational journal of molecular sciences · 2023Article
- Cholesterol catalyzes unfolding in membrane-inserted motifs of the pore forming protein cytolysin A.Biophysical journal · 2023Article
- Coarse-grained modeling of polystyrene-modified CNTs and their interactions with lipid bilayers.Biophysical journal · 2023Article
- Membrane Models and Experiments Suitable for Studies of the Cholesterol Bilayer Domains.Membranes · 2023Review
- Molecular oxygen as a probe molecule in EPR spin-labeling studies of membrane structure and dynamics.Oxygen (Basel, Switzerland) · 2022Article
- Membrane elasticity modulated by cholesterol in model of porcine eye lens-lipid membrane.Experimental eye research · 2022Article
- Multilamellar Liposomes as a Model for Biological Membranes: Saturation Recovery EPR Spin-Labeling Studies.Membranes · 2022Review
- Mechanical properties of the high cholesterol-containing membrane: An AFM study.Biochimica et biophysica acta. Biomembranes · 2021Article
- Functional Group Distributions, Partition Coefficients, and Resistance Factors in Lipid Bilayers Using Site Identification by Ligand Competitive Saturation.Journal of chemical theory and computation · 2021Article
- Effects of cholesterol on chlorzoxazone translocation across POPC bilayer.Journal of molecular modeling · 2021Article
- Lutein and Zeaxanthin in the Lipid Bilayer-Similarities and Differences Revealed by Computational Studies.Frontiers in molecular biosciences · 2021Article
- Confocal Microscopy Confirmed that in Phosphatidylcholine Giant Unilamellar Vesicles with very High Cholesterol Content Pure Cholesterol Bilayer Domains Form.Cell biochemistry and biophysics · 2019Article
- Asymmetric Spontaneous Intercalation of Lutein into a Phospholipid Bilayer, a Computational Study.Computational and structural biotechnology journal · 2019Article
- Is the cholesterol bilayer domain a barrier to oxygen transport into the eye lens?Biochimica et biophysica acta. Biomembranes · 2018Article
- Cholesterol Bilayer Domains in the Eye Lens Health: A Review.Cell biochemistry and biophysics · 2017Review
- High Cholesterol/Low Cholesterol: Effects in Biological Membranes: A Review.Cell biochemistry and biophysics · 2017Review
- Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.Science signaling · 2017Article
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3 authors.
Funding
Abstract
Molecular dynamics (MD) simulations of a mono-cis-unsaturated 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) bilayer and a POPC bilayer containing 50mol% cholesterol (POPC-Chol50) were carried out for 200ns to compare the spatial organizations of the pure POPC bilayer and the POPC bilayer saturated with Chol. The results presented here indicate that saturation with Chol significantly narrows the distribution of vertical positions of the center-of-mass of POPC molecules and POPC atoms in the bilayer. In the POPC-Chol50 bilayer, the same moieties of the lipid molecules are better aligned at a given bilayer depth, forming the following clearly separated membrane regions: the polar headgroup, the rigid core consisting of steroid rings and upper fragments of the acyl chains, and the fluid hydrocarbon core consisting of Chol chains and the lower fragments of POPC chains. The membrane surface of the POPC-Chol50 bilayer is smooth. The results have biological significance because the POPC-Chol50 bilayer models the bulk phospholipid portion of the fiber-cell membrane in the eye lens. It is hypothesized that in the eye lens cholesterol-induced smoothing of the membrane surface decreases light-scattering and helps to maintain lens transparency.
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