ArticleBehavioural brain research2012
Long-term effects of neonatal stress on adult conditioned place preference (CPP) and hippocampal neurogenesis.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Pediatric sleep and pain: etiologies, consequences, and clinical considerations.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Review
- Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice.Frontiers in pharmacology · 2022Article
- Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations.Cold Spring Harbor perspectives in medicine · 2021Review
- Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance.European journal of psychotraumatology · 2021Article
- Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula.Neurobiology of stress · 2020Article
- Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system.Alcohol (Fayetteville, N.Y.) · 2018Review
- Modeling prenatal opioid exposure in animals: Current findings and future directions.Frontiers in neuroendocrinology · 2018Review
- Opioid analgesia and the somatosensory memory of neonatal surgical injury in the adult rat.British journal of anaesthesia · 2018Article
- Neonatal abstinence syndrome and early childhood morbidity and mortality in Washington state: a retrospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Increased cocaine-induced conditioned place preference during periadolescence in maternally separated male BALB/c mice: the role of cortical BDNF, microRNA-212, and MeCP2.Psychopharmacology · 2016Article
- Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines.Psychoneuroendocrinology · 2016Article
- Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice.PloS one · 2016Article
- Dose-dependent effects of morphine exposure on mRNA and microRNA (miR) expression in hippocampus of stressed neonatal mice.PloS one · 2015Article
- Early life stress and hippocampal neurogenesis in the neonate: sexual dimorphism, long term consequences and possible mediators.Frontiers in molecular neuroscience · 2015Review
- Article
- The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.The international journal of neuropsychopharmacology · 2013Article
- Adult responses to an ischemic stroke in a rat model of neonatal stress and morphine treatment.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction.Psychopharmacology · 2012Review
- The effects of lobeline and naltrexone on methamphetamine-induced place preference and striatal dopamine and serotonin levels in adolescent rats with a history of maternal separation.Metabolic brain disease · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Critically ill preterm infants are often exposed to stressors that may affect neurodevelopment and behavior. We reported that exposure of neonatal mice to stressors or morphine produced impairment of adult morphine-rewarded conditioned place preference (CPP) and altered hippocampal gene expression. We now further this line of inquiry by examining both short- and long-term effects of neonatal stress and morphine treatment. Neonatal C57BL/6 mice were treated twice daily from postnatal day (P) 5 to P9 using different combinations of factors. Subsets received saline or morphine injections (2mg/kgs.c.) or were exposed to our neonatal stress protocol (maternal separation 8h/d × 5d+gavage feedings ± hypoxia/hyperoxia). Short-term measures examined on P9 were neuronal fluorojade B and bromodeoxyuridine staining, along with urine corticosterone concentrations. Long-term measures examined in adult mice (>P60) included CPP learning to cocaine reward (± the kappa opioid receptor (KOR) agonist U50,488 injection), and adult hippocampal neurogenesis (PCNA immunolabeling). Neonatal stress (but not morphine) decreased the cocaine-CPP response and this effect was reversed by KOR stimulation. Both neonatal stress or morphine treatment increased hippocampal neurogenesis in adult mice. We conclude that reduced learning and increased hippocampal neurogenesis are both indicators that neonatal stress desensitized mice and reduced their arousal and stress responsiveness during adult CPP testing. Reconciled with other findings, these data collectively support the stress inoculation hypothesis whereby early life stressors prepare animals to tolerate future stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.