ArticleDevelopmental biology2012
Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 41 citations in OpenAlex.
- Transcriptome-Wide Analysis of Brain Cancer Initiated by Polarity Disruption inInternational journal of molecular sciences · 2025Article
- Transfer RNA Levels Are Tuned to Support Differentiation During Drosophila Neurogenesis.Genes · 2024Article
- Transfer RNA levels are tuned to support differentiation during Drosophila neurogenesis.bioRxiv : the preprint server for biology · 2024Article
- A cell atlas of the larval Aedes aegypti ventral nerve cord.Neural development · 2024Article
- mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons.Neural development · 2022Article
- Functional analysis of enhancer elements regulating the expression of the Drosophila homeodomain transcription factor DRx by gene targeting.Hereditas · 2021Article
- Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors.PLoS genetics · 2021Article
- DigiTAG-a RNA Sequencing Approach to Analyze Transcriptomes of Rare Cell Populations inBio-protocol · 2020Article
- Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors duringGenes & development · 2018Article
- Drosophila nucleostemin 3 is required to maintain larval neuroblast proliferation.Developmental biology · 2018Article
- The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.eLife · 2018Article
- Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours inBioMed research international · 2017Article
- The insect central complex as model for heterochronic brain development-background, concepts, and tools.Development genes and evolution · 2016Review
- Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila.Genetics · 2016Article
- An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system.Developmental biology · 2015Article
- Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal.Developmental neurobiology · 2015Article
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- Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain.Neural development · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila larval central brain contains about 10,000 differentiated neurons and 200 scattered neural progenitors (neuroblasts), which can be further subdivided into ~95 type I neuroblasts and eight type II neuroblasts per brain lobe. Only type II neuroblasts generate self-renewing intermediate neural progenitors (INPs), and consequently each contributes more neurons to the brain, including much of the central complex. We characterized six different mutant genotypes that lead to expansion of neuroblast numbers; some preferentially expand type II or type I neuroblasts. Transcriptional profiling of larval brains from these mutant genotypes versus wild-type allowed us to identify small clusters of transcripts enriched in type II or type I neuroblasts, and we validated these clusters by gene expression analysis. Unexpectedly, only a few genes were found to be differentially expressed between type I/II neuroblasts, suggesting that these genes play a large role in establishing the different cell types. We also identified a large group of genes predicted to be expressed in all neuroblasts but not in neurons. We performed a neuroblast-specific, RNAi-based functional screen and identified 84 genes that are required to maintain proper neuroblast numbers; all have conserved mammalian orthologs. These genes are excellent candidates for regulating neural progenitor self-renewal in Drosophila and mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.