Evidence map›Paper›PMID 22061264›Full record

ArticleJournal of feline medicine and surgery2011

Mycobacterial disease in a population of 339 cats in Great Britain: II. Histopathology of 225 cases, and treatment and outcome of 184 cases.

Danièlle A Gunn-Moore, Sarah E McFarland, Alex Schock, Jacqueline I Brewer, Tim R Crawshaw, Richard S Clifton-Hadley, Darren J Shaw

Open access · greenAbstract read
In one paragraph

Article in Journal of feline medicine and surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 53 citations in OpenAlex.

  1. Feline Cutaneous Mycobacteriosis Caused byAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Article
  4. One health (Amsterdam, Netherlands) · 2025
    Article
  5. First Case Report of Successful Treatment ofAnimals : an open access journal from MDPI · 2025
    Article
  6. Article
  7. Review
  8. Ocular mycobacterial lesions in cats.Veterinary pathology · 2022
    Article
  9. Article
  10. SystemicPathogens (Basel, Switzerland) · 2020
    Article
  11. The Canadian veterinary journal = La revue veterinaire canadienne · 2020
    Article
  12. Tuberculosis due toJournal of feline medicine and surgery · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Nosocomial spread of Mycobacterium bovis in domestic cats.Journal of feline medicine and surgery · 2015
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Danièlle A Gunn-MooreRoyal (Dick) School of Veterinary Studies and The Roslin Institute, Division of Clinical Veterinary Sciences, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, Scotland EH25 9RG, UK. Danielle.Gunn-Moore@ed.ac.uk
Sarah E McFarland
Alex Schock
Jacqueline I Brewer
Tim R Crawshaw
Richard S Clifton-Hadley
Darren J Shaw
Roslin Institute · GBVeterinary Medicines Directorate · GBUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated 339 cases of feline mycobacterial infection, with histopathology findings from 225 cases, and treatment and outcome information from 184 cases. Tissue samples from cats with cutaneous lesions or suspicious masses at exploratory laparotomy were submitted to the Veterinary Laboratories Agency for mycobacterial culture over a 4-year period to December 2008. The study reviewed the files for information about histopathology, treatment and outcome, and blindly reviewed histopathological changes (including staining for acid-fast bacteria [AFB]) in a sub-set of 45 cases. When a cat is suspected of having a mycobacterial infection, accurate identification of the species involved helps to determine possible treatment options and prognosis. The study confirmed that histopathology and the presence of AFB are useful tools in the recognition of mycobacterial infection. Unfortunately, they did little to help determine the species of mycobacteria involved. The study identified a group of cats that were negative for AFB at the primary laboratory, but from which mycobacteria could be cultured; commonly Mycobacterium bovis or Mycobacterium microti. The study also identified a group of cats which where culture negative, despite typical signs of mycobacterial infection and positive AFB staining. Many cases responded favourably to treatment (56% of the cases where information was available), and many cats gained complete remission (42%). However, relapses were common (64%) and often followed by pulmonary and/or systemic spread that may have resulted from treatment with short courses of single drugs. This study shows that the diagnosis and treatment of feline mycobacteriosis is complex and challenging.

Indexed as

AnimalsAnti-Bacterial AgentsCat DiseasesCatsFemaleFluoroquinolonesLaboratoriesMacrolidesMaleMycobacteriumMycobacterium InfectionsPolymerase Chain ReactionTetracyclineUnited KingdomAnti-Bacterial AgentsFluoroquinolonesMacrolidesTetracycline

Identifiers

PMID22061264
PMCPMC10832975
OpenAlexW2048895235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.