ArticleMolecular ecology2011
Asymmetric introgression between the M and S forms of the malaria vector, Anopheles gambiae, maintains divergence despite extensive hybridization.
Article in Molecular ecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 81 citations in OpenAlex.
- Phenotypic evidence of deltamethrin resistance and identification of selective sweeps in Anopheles mosquitoes on the Bijagós Archipelago, Guinea-Bissau.Scientific reports · 2024Article
- The fitness of an introgressing haplotype changes over the course of divergence and depends on its size and genomic location.PLoS biology · 2023Article
- The role of recombination landscape in species hybridisation and speciation.Frontiers in plant science · 2023Review
- Conceptual risk assessment of mosquito population modification gene-drive systems to control malaria transmission: preliminary hazards list workshops.Frontiers in bioengineering and biotechnology · 2023Article
- Perfect association between spatial swarm segregation and the X-chromosome speciation island in hybridizing Anopheles coluzzii and Anopheles gambiae populations.Scientific reports · 2022Article
- Novel genotyping approaches to easily detect genomic admixture between the major Afrotropical malaria vector species, Anopheles coluzzii and An. gambiae.Molecular ecology resources · 2021Article
- Unravelling population structure heterogeneity within the genome of the malaria vector Anopheles gambiae.BMC genomics · 2021Article
- The origin of island populations of the African malaria mosquito, Anopheles coluzzii.Communications biology · 2021Article
- The use of islands and cluster-randomized trials to investigate vector control interventions: a case study on the Bijagós archipelago, Guinea-Bissau.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Genome-Scale Phylogenetic and Population Genetic Studies Provide Insight Into Introgression and Adaptive Evolution ofFrontiers in genetics · 2021Article
- Evaluating the probability of CRISPR-based gene drive contaminating another species.Evolutionary applications · 2020Article
- Genomic differentiation and intercontinental population structure of mosquito vectors Culex pipiens pipiens and Culex pipiens molestus.Scientific reports · 2020Article
- Linked-read sequencing identifies abundant microinversions and introgression in the arboviral vector Aedes aegypti.BMC biology · 2020Article
- A survey of Anopheles species composition and insecticide resistance on the island of Bubaque, Bijagos Archipelago, Guinea-Bissau.Malaria journal · 2020Article
- Assessment of the ecologically dependent post-zygotic isolation between Anopheles coluzzii and Anopheles gambiae.PloS one · 2020Article
- In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in theG3 (Bethesda, Md.) · 2019Article
- Article
- Transcontinental dispersal ofCommunications biology · 2019Article
- Article
- Evidence for Introgression Among Three Species of theFrontiers in genetics · 2018Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The suggestion that genetic divergence can arise and/or be maintained in the face of gene flow has been contentious since first proposed. This controversy and a rarity of good examples have limited our understanding of this process. Partially reproductively isolated taxa have been highlighted as offering unique opportunities for identifying the mechanisms underlying divergence with gene flow. The African malaria vector, Anopheles gambiae s.s., is widely regarded as consisting of two sympatric forms, thought by many to represent incipient species, the M and S molecular forms. However, there has been much debate about the extent of reproductive isolation between M and S, with one view positing that divergence may have arisen and is being maintained in the presence of gene flow, and the other proposing a more advanced speciation process with little realized gene flow because of low hybrid fitness. These hypotheses have been difficult to address because hybrids are typically rare (<1%). Here, we assess samples from an area of high hybridization and demonstrate that hybrids are fit and responsible for extensive introgression. Nonetheless, we show that strong divergent selection at a subset of loci combined with highly asymmetric introgression has enabled M and S to remain genetically differentiated despite extensive gene flow. We propose that the extent of reproductive isolation between M and S varies across West Africa resulting in a 'geographic mosaic of reproductive isolation'; a finding which adds further complexity to our understanding of divergence in this taxon and which has considerable implications for transgenic control strategies.
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