ArticlePain research & management
Postoperative respiratory depression with pregabalin: a case series and a preoperative decision algorithm.
Article in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy: A Randomized Clinical Trial.JAMA neurology · 2021Trial
- Sedative effects of oral pregabalin premedication on intravenous sedation using propofol target-controlled infusion.Journal of anesthesia · 2017Trial
- Targeting γ-aminobutyric acid type A receptors to mitigate perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- Network Meta-analysis of Randomized Controlled Trials Assessing Neuromodulation Therapies for Painful Diabetic Neuropathy.Neurology and therapy · 2025Article
- Signal mining and analysis for central nervous system adverse events due to taking oxycodone based on FAERS database.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Prevalence of Gabapentinoids and Central Nervous System Depressant Drugs, and Their Association with Risk Factors for Respiratory Depression in Primary Care Patients.Clinical drug investigation · 2022Article
- Review
- Treating restless legs syndrome in the context of sleep disordered breathing comorbidity.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Perioperative use of gabapentinoids for the management of postoperative acute pain: protocol of a systematic review and meta-analysis.Systematic reviews · 2019Article
- Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study.PLoS medicine · 2017Observational
- Risk of respiratory depression with opioids and concomitant gabapentinoids.Journal of pain research · 2017Article
- Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain.Therapeutic advances in drug safety · 2014Review
- A protocol for a systematic review for perioperative pregabalin use.Systematic reviews · 2012Article
- Perioperative Pain Management in Bariatric Anesthesia.Saudi journal of anaesthesiaReview
- Does multimodal analgesia premedication improve the management of carcinoma cervix brachytherapy?Pain research & managementArticle
- Retrospective analysis of the clinical effect of spinal cord stimulation in the treatment of painful diabetic peripheral neuropathy.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregabalin is gaining popularity in the perioperative period for its usefulness in treating neuropathic pain and its apparent opioid- sparing effect. The present report describes the perioperative course of three patients who received pregabalin and experienced significant respiratory depression in the postoperative period. All three patients consented to the report and publication of the present case series. The first patient was elderly with borderline renal dysfunction. She experienced respiratory arrest in the immediate postoperative period following a craniotomy for tumour excision. The second patient presented with severe respiratory depression 12 h after receiving a spinal anesthetic for joint replacement, and was later found to have clinically significant obstructive sleep apnea. The third patient, who was an otherwise healthy elderly individual on benzodiazepines for anxiety, experienced respiratory arrest in the postanesthesia care unit after an uneventful anesthesia for lumbar spine decompression. All of these patients were treated successfully with standard resuscitation measures. Although other causes of respiratory depression in these patients were considered, there appears to be an association between pregabalin and this complication. The present article briefly reviews the evidence regarding the perioperative use of pregabalin. Based on the authors' experience and the available evidence, they believe that pregabalin may be useful in the management of acute pain in carefully selected patients undergoing certain surgeries. A clinical algorithm has been developed to guide the perioperative use of pregabalin. This algorithm may be helpful in increasing the safety of perioperative pregabalin use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.