Evidence map›Paper›PMID 22059114›Full record

ReviewTherapeutic delivery2011

Phase-shift, stimuli-responsive drug carriers for targeted delivery.

Brian E O'Neill, Natalya Rapoport

Abstract readReview
In one paragraph

Review in Therapeutic delivery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Acoustomechanically activatable liposomes for ultrasonic drug uncaging.bioRxiv : the preprint server for biology · 2023
    Article
  3. Review
  4. Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Acoustic droplet vaporization in biology and medicine.BioMed research international · 2013
    Review
  12. Article
  13. Microfluidic generation of acoustically active nanodroplets.Small (Weinheim an der Bergstrasse, Germany) · 2012
    Article
  14. Review
  15. Current status and prospects for microbubbles in ultrasound theranostics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian E O'NeillDepartment of Translational Imaging, The Methodist Hospital Research Institute, MC R6-414, 6670 Bertner Street, Houston, TX 77030, USA.
Natalya Rapoport

Funding

Acoustically Activated Micellar Drug DeliveryR01EB001033 · NIBIB · UNIVERSITY OF UTAH · PI RAPOPORT, NATALYA Y · 2002 to 2010
$2.1M
NIBIB NIH HHS R01 EB001033NIBIB NIH HHS R01 EB1033
6 · The paper itself

Abstract

The intersection of particles and directed energy is a rich source of novel and useful technology that is only recently being realized for medicine. One of the most promising applications is directed drug delivery. This review focuses on phase-shift nanoparticles (that is, particles of submicron size) as well as micron-scale particles whose action depends on an external-energy triggered, first-order phase shift from a liquid to gas state of either the particle itself or of the surrounding medium. These particles have tremendous potential for actively disrupting their environment for altering transport properties and unloading drugs. This review covers in detail ultrasound and laser-activated phase-shift nano- and micro-particles and their use in drug delivery. Phase-shift based drug-delivery mechanisms and competing technologies are discussed.

Indexed as

Drug CarriersDrug Delivery SystemsNanoparticlesAnimalsBiological TransportHumansLasersParticle SizePhase TransitionTechnology, PharmaceuticalUltrasonographyDrug Carriers

Identifiers

PMID22059114
PMCPMC3207214

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.