ArticleInterdisciplinary toxicology2011
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function.
Article in Interdisciplinary toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Allosteric Modulation of SERCA Pumps in Health and Disease: Structural Dynamics, Posttranslational Modifications, and Therapeutic Potential.Journal of molecular biology · 2025Review
- Potential of functional flavonoids in targeting vasospasm through modulation of oxidative stress and SPC-induced signaling pathways.Frontiers in pharmacology · 2025Review
- From traditional medicine to nanomedicine: potential ofRSC medicinal chemistry · 2024Review
- The Potential of the Flavonoid Content ofMetabolites · 2023Review
- Natural Polyphenols as SERCA Activators: Role in the Endoplasmic Reticulum Stress-Related Diseases.Molecules (Basel, Switzerland) · 2022Review
- Eriodictyol Attenuates HNutrients · 2022Article
- Can Polyphenols Inhibit Ferroptosis?Antioxidants (Basel, Switzerland) · 2022Review
- Modelling and targeting mitochondrial protein tyrosine phosphatase 1: a computational approach.In silico pharmacology · 2022Article
- Bioflavonoid-Induced Apoptosis and DNA Damage in Amastigotes and Promastigotes ofMolecules (Basel, Switzerland) · 2021Article
- A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes.Molecular biology reports · 2021Article
- A Walk in the Memory, from the First Functional Approach up to Its Regulatory Role of Mitochondrial Bioenergetic Flow in Health and Disease: Focus on the Adenine Nucleotide Translocator.International journal of molecular sciences · 2021Review
- Maillard Reaction Products in Gluten-Free Bread Made from Raw and Roasted Buckwheat Flour.Molecules (Basel, Switzerland) · 2021Article
- Polymethoxyselenoflavones exert anti-obesity effects through activation of lipolysis and brown adipocyte metabolism.International journal of obesity (2005) · 2021Article
- HydroethanolicFrontiers in pharmacology · 2021Article
- Flavonoid bioactive compounds of hawthorn extract can promote growth, regulate electrocardiogram waves, and improve cardiac parameters of pulmonary hypertensive chickens.Poultry science · 2020Article
- Cardioprotective Effect ofFrontiers in pharmacology · 2016Article
- Synthesis and Evaluation of Neuroprotective Selenoflavanones.International journal of molecular sciences · 2015Article
- Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1.Molecular and cellular biochemistry · 2014Article
- Quercetin inhibits degranulation and superoxide generation in PMA stimulated neutrophils.Interdisciplinary toxicology · 2012Article
- Cerebroprotective activity ofIndian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca(2+)-ATPases belong to the main calcium regulating proteins involved in the balance of calcium homeostasis, which is impaired in oxidative/nitrosative stress and related diseases or aging. The mechanisms of Ca(2+)-ATPases dysfunction are discussed, focusing on cystein oxidation and tyrosine nitration. Flavonoids act not only as antioxidants but are also able to bind directly to Ca(2+)-ATPases, thus changing their conformation, which results in modulation of enzyme activity.Dysfunction of Ca(2+)-ATPases is summarized with respect to their posttranslational and conformational changes in diseases related to oxidative/nitrosative stress and aging. Ca(2+)-ATPases are discussed as a therapeutic tool and the possible role of flavonoids in this process is suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.