ArticleIEEE journal of quantum electronics2009
High-Speed Nonlinear Interferometric Vibrational Imaging of Biological Tissue With Comparison to Raman Microscopy.
Article in IEEE journal of quantum electronics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Coherent anti-Stokes Raman scattering microscopy: overcoming technical barriers for clinical translation.Journal of biophotonics · 2014Review
- The Gold Nanorod-Biology Interface: From Proteins to Cells to Tissue.Current physical chemistry · 2013Article
- Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis.Analytical chemistry · 2013Article
- Tissue refractive index as marker of disease.Journal of biomedical optics · 2011Article
- Nonlinear interferometric vibrational imaging for fast label-free visualization of molecular domains in skin.Analytical and bioanalytical chemistry · 2011Article
- Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging.Cancer research · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Vibrational contrast imaging of the distribution of complex biological molecules requires the use of techniques that provide broadband spectra with sufficient resolution. Coherent anti-Stokes Raman scattering (CARS) microscopy is currently limited in meeting these requirements due to the presence of a nonresonant background and its inability to target multiple resonances simultaneously. We present nonlinear interferometric vibrational imaging (NIVI), a technique based on CARS that uses femtosecond pump and Stokes pulses to retrieve broadband vibrational spectra over 200 cm(-1) (full-width at half maximum). By chirping the pump and performing spectral interferometric detection, the anti-Stokes pulses are resolved in time. This phase-sensitive detection allows suppression of not only the nonresonant background, but also of the real part of the nonlinear susceptibility χ((3)), improving the spectral resolution and features to make them comparable to those acquired with spontaneous Raman microscopy, as shown for a material sample and mammary tissue.
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Registered trials
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