ArticleJournal of neural engineering2011
Inhibitory feedback promotes stability in an oscillatory network.
Article in Journal of neural engineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- IeLife · 2024Article
- IbioRxiv : the preprint server for biology · 2024Article
- Neuropeptide Modulation Enables Biphasic Internetwork Coordination via a Dual-Network Neuron.eNeuro · 2024Article
- Modulation by Neuropeptides with Overlapping Targets Results in Functional Overlap in Oscillatory Circuit Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Connectomic analysis of theeLife · 2022Article
- Robust dynamical invariants in sequential neural activity.Scientific reports · 2019Article
- Flexor and Extensor Ankle Afferents Broadly Innervate Locomotor Spinal Shox2 Neurons and Induce Similar Effects in Neonatal Mice.Frontiers in cellular neuroscience · 2019Article
- Asymmetry Factors Shaping Regular and Irregular Bursting Rhythms in Central Pattern Generators.Frontiers in computational neuroscience · 2017Article
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- Membrane potential resonance frequency directly influences network frequency through electrical coupling.Journal of neurophysiology · 2016Article
- Feedback control of variability in the cycle period of a central pattern generator.Journal of neurophysiology · 2015Article
- Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms.Current opinion in neurobiology · 2015Review
- The significance of dynamical architecture for adaptive responses to mechanical loads during rhythmic behavior.Journal of computational neuroscience · 2015Article
- The frequency preference of neurons and synapses in a recurrent oscillatory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effects of synaptic plasticity on phase and period locking in a network of two oscillatory neurons.Journal of mathematical neuroscience · 2014Article
- Phase response properties of half-center oscillators.Journal of computational neuroscience · 2013Article
- Neuropeptide modulation of microcircuits.Current opinion in neurobiology · 2012Review
- Small is beautiful: models of small neuronal networks.Current opinion in neurobiology · 2012Review
- Peptide neuromodulation of synaptic dynamics in an oscillatory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Reliability and variability of neuronal activity are both thought to be important for the proper function of neuronal networks. The crustacean pyloric rhythm (∼1 Hz) is driven by a group of pacemaker neurons (AB/PD) that inhibit and burst out of phase with all follower pyloric neurons. The only known chemical synaptic feedback to the pacemakers is an inhibitory synapse from the follower lateral pyloric (LP) neuron. Although this synapse has been studied extensively, its role in the generation and coordination of the pyloric rhythm is unknown. We examine the hypothesis that this synapse acts to stabilize the oscillation by reducing the variability in cycle period on a cycle-by-cycle basis. Our experimental data show that functionally removing the LP-pyloric dilator (PD) synapse by hyperpolarizing the LP neuron increases the pyloric period variability. The increase in pyloric rhythm stability in the presence of the LP-PD synapse is demonstrated by a decrease in the amplitude of the phase response curve of the PD neuron. These experimental results are explained by a reduced mathematical model. Phase plane analysis of this model demonstrates that the effect of the periodic inhibition is to produce asymptotic stability in the oscillation phase, which leads to a reduction in variability of the oscillation cycle period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.