ArticleHaematologica2012
In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior.
Article in Haematologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
- Non-Hodgkin's lymphomas, version 4.2014.Journal of the National Comprehensive Cancer Network : JNCCN · 2014Guideline
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- Precursory or early lesions of follicular lymphoma: clinical features, pathology, and genetics.Journal of clinical and experimental hematopathology : JCEH · 2023Review
- Chronic lymphocytic leukaemia/small lymphocytic lymphoma and mantle cell lymphoma: from early lesions to transformation.Virchows Archiv : an international journal of pathology · 2023Review
- CD5-negative mantle cell lymphoma: clinicopathologic features of an indolent variant that confers a survival advantage.Leukemia & lymphoma · 2022Article
- Multifocal in situ mantle cell neoplasia of the ileocecal region: a case report with simultaneous nodal and extranodal involvement.Virchows Archiv : an international journal of pathology · 2021Article
- The pathologic diagnosis of mantle cell lymphoma.Histology and histopathology · 2021Review
- SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Clinicopathological and Immunohistochemical Profile of Mantle Cell Lymphoma: An Institutional Experience.Cureus · 2021Article
- Non-coding RNAs (miRNAs and lncRNAs) and their roles in lymphogenesis in all types of lymphomas and lymphoid malignancies.Oncology letters · 2021Review
- High Counts of CD68+ and CD163+ Macrophages in Mantle Cell Lymphoma Are Associated With Inferior Prognosis.Frontiers in oncology · 2021Article
- An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2020Article
- Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas.Cold Spring Harbor perspectives in medicine · 2020Review
- Molecular Pathogenesis of Mantle Cell Lymphoma.Hematology/oncology clinics of North America · 2020Review
- The broad landscape of follicular lymphoma: Part II.Pathologica · 2020Review
- Simultaneous Presentation of Leukemic Non-Nodal Mantle Cell Lymphoma and Gamma-Delta T-Large Granular Lymphocytic Leukemia in a Patient with Rheumatoid Arthritis.Cancer management and research · 2020Article
- Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma.Genes & diseases · 2019Article
- Ontogeny, Genetics, Molecular Biology, and Classification of B- and T-Cell Non-Hodgkin Lymphoma.Hematology/oncology clinics of North America · 2019Review
- [Revised version of the 4th edition of the WHO classification of malignant lymphomas : What is new?]Der Pathologe · 2019Review
- [Clonal evolution of early lymphoproliferations].Der Pathologe · 2018Review
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Authors and funding
20 authors at 12 institutions in 5 countries.
Funding
Abstract
backgroundCyclin D1-positive B cells are occasionally found in the mantle zones of reactive lymphoid follicles, a condition that has been called "in situ mantle cell lymphoma". The clinical significance of this lesion remains uncertain. DESIGN AND
methodsThe clinical and pathological characteristics, including SOX11 expression, of 23 cases initially diagnosed as in situ mantle cell lymphoma were studied.
resultsSeventeen of the 23 cases fulfilled the criteria for in situ mantle cell lymphoma. In most cases, the lesions were incidental findings in reactive lymph nodes. The t(11;14) was detected in all eight cases examined. SOX11 was positive in seven of 16 cases (44%). Five cases were associated with other small B-cell lymphomas. In two cases, both SOX11-positive, the in situ mantle cell lymphoma lesions were discovered after the diagnosis of overt lymphoma; one 4 years earlier, and one 3 years later. Twelve of the remaining 15 patients had a follow-up of at least 1 year (median 2 years; range, 1-19.5), of whom 11 showed no evidence of progression, including seven who were not treated. Only one of 12 patients with an in situ mantle cell lymphoma lesion and no diagnosis of mantle cell lymphoma at the time developed an overt lymphoma, 4 years later; this case was also SOX11-positive. The six remaining cases were diagnosed as mantle cell lymphoma with a mantle zone pattern. Five were SOX11-positive and four of them were associated with lymphoma without a mantle zone pattern.
conclusionsIn situ mantle cell lymphoma lesions are usually an incidental finding with a very indolent behavior. These cases must be distinguished from mantle cell lymphoma with a mantle zone pattern and overt mantle cell lymphoma because they may not require therapeutic intervention.
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