ArticlePediatric pulmonology2012
Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model.
Article in Pediatric pulmonology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Postnatal growth restriction impairs rat lung structure and function.Anatomical record (Hoboken, N.J. : 2007) · 2025Article
- Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.Pediatric pulmonology · 2021Article
- Early extubation to noninvasive respiratory support of former preterm lambs improves long-term respiratory outcomes.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Asthma prevalence, lung and cardiovascular function in adolescents born preterm.Scientific reports · 2020Article
- Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension.Biomedicines · 2020Article
- Role of miR-29 in mediating offspring lung phenotype in a rodent model of intrauterine growth restriction.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Former-preterm lambs have persistent alveolar simplification at 2 and 5 months corrected postnatal age.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Neonatal and Long-Term Consequences of Fetal Growth Restriction.Current pediatric reviews · 2018Review
- Alveolar formation is dysregulated by restricted nutrition but not excess sedation in preterm lambs managed by noninvasive support.Pediatric research · 2016Article
- Short- and long-term effects of a maternal low-energy diet ad libitum during gestation and/or lactation on physiological parameters of mothers and male offspring.European journal of nutrition · 2015Article
- Epigenetic contributions to the developmental origins of adult lung disease.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2015Review
- Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Vitamin D supplementation blocks pulmonary structural and functional changes in a rat model of perinatal vitamin D deficiency.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Nebulized PPARγ agonists: a novel approach to augment neonatal lung maturation and injury repair in rats.Pediatric research · 2014Article
- Metyrapone blocks maternal food restriction-induced changes in female rat offspring lung development.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Curcumin protects the developing lung against long-term hyperoxic injury.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Intrauterine growth restriction transiently delays alveolar formation and disrupts retinoic acid receptor expression in the lung of female rat pups.Pediatric research · 2013Article
- Retinoic acid rescues alveolar hypoplasia in the calorie-restricted developing rat lung.American journal of respiratory cell and molecular biology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Intrauterine growth restriction (IUGR) increases the risk of respiratory compromise throughout postnatal life. However, the molecular mechanism(s) underlying the respiratory compromise in offspring following IUGR is not known. We hypothesized that IUGR following maternal food restriction (MFR) would affect extracellular matrix deposition in the lung, explaining the long-term impairment in pulmonary function in the IUGR offspring. Using a well-established rat model of MFR during gestation to produce IUGR pups, we found that at postnatal day 21, and at 9 months (9M) of age the expression and abundance of elastin and alpha smooth muscle actin (αSMA), two key extracellular matrix proteins, were increased in IUGR lungs when compared to controls (P < 0.05, n = 6), as determined by both Western and immunohistochemistry analyses. Compared to controls, the MFR group showed no significant change in pulmonary resistance at baseline, but did have significantly decreased pulmonary compliance at 9M (P < 0.05 vs. control, n = 5). In addition, MFR lungs exhibited increased responsiveness to methacholine challenge. Furthermore, exposing cultured fetal rat lung fibroblasts to serum deprivation increased the expression of elastin and elastin-related genes, which was blocked by serum albumin supplementation, suggesting protein deficiency as the predominant mechanism for increased pulmonary elastin deposition in IUGR lungs. We conclude that accompanying the changes in lung function, consistent with bronchial hyperresponsiveness, expression of the key alveolar extracellular matrix proteins elastin and αSMA increased in the IUGR lung, thus providing a potential explanation for the compromised lung function in IUGR offspring.
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