ReviewImmunologic research2011
Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes.
Review in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Factors contributing to the potency of CD8Trends in immunology · 2023Review
- Inflammatory cell death: how macrophages sense neighbouring cell infection and damage.Biochemical Society transactions · 2023Review
- The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection.Nature communications · 2022Article
- Potential Impact of Human Cytomegalovirus Infection on Immunity to Ovarian Tumours and Cancer Progression.Biomedicines · 2021Review
- Phenotypical and Functional Characterization of Cytotoxic Unconventional T-Cells.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Rapamycin Re-Directs Lysosome Network, Stimulates ER-Remodeling, Involving Membrane CD317 and Affecting Exocytosis, inInternational journal of molecular sciences · 2020Article
- Human CD8+ T Cells Release Extracellular Traps Co-Localized With Cytotoxic Vesicles That Are Associated With Lesion Progression and Severity in Human Leishmaniasis.Frontiers in immunology · 2020Article
- Aurora A controls CD8Scientific reports · 2019Article
- Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue.Journal of visualized experiments : JoVE · 2018Article
- T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy.Laboratory investigation; a journal of technical methods and pathology · 2017Review
- Article
- CD8+ T cell exhaustion, suppressed gamma interferon production, and delayed memory response induced by chronic Brucella melitensis infection.Infection and immunity · 2015Article
- Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner.The Journal of biological chemistry · 2015Article
- Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health.The British journal of nutrition · 2013Article
- Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner.Cell reports · 2013Article
- Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cytotoxic T lymphocytes (CTL) play a critical role in immunity against viruses and cancer. The antigen receptor or T-cell receptor (TCR) on CTL determines the specificity toward target cells. The CD8 co-receptor functions in concert with the TCR to enhance TCR-mediated signaling, accounting for the remarkable sensitivity and swift signaling kinetics of the CTL response. The latter ensures efficient delivery and release of lytic granules, resulting in sensitive and rapid destruction of target cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.