ArticleThe Journal of membrane biology2011
Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals.
Article in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Quantifying calretinin-labeled afferent terminals in vestibular sensory epithelia of young and older gerbils.Neurobiology of aging · 2026Article
- A Regional Ultrastructural Analysis of the Cellular and Synaptic Architecture of the Mouse Vestibular Periphery, With Reference to the Chinchilla.The Journal of comparative neurology · 2025Article
- Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci.International journal of molecular sciences · 2024Article
- Expression of hyperpolarization-activated current (Journal of neurophysiology · 2023Article
- Cholinergic Modulation of Membrane Properties of Calyx Terminals in the Vestibular Periphery.Neuroscience · 2021Article
- Dopaminergic Inhibition of NaFrontiers in neuroscience · 2021Article
- Activation of GABAJournal of neurophysiology · 2020Article
- Persistent and resurgent NaJournal of neurophysiology · 2020Article
- KNeuroscience · 2020Article
- Regional and Developmental Differences in NaFrontiers in cellular neuroscience · 2018Article
- An allosteric gating model recapitulates the biophysical properties of IThe Journal of physiology · 2017Article
- AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents.Journal of neurophysiology · 2017Article
- Kv1 channels and neural processing in vestibular calyx afferents.Frontiers in systems neuroscience · 2015Article
- Zonal variations in K+ currents in vestibular crista calyx terminals.Journal of neurophysiology · 2015Article
- Preliminary characterization of voltage-activated whole-cell currents in developing human vestibular hair cells and calyx afferent terminals.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Activation of μ-opioid receptors inhibits calcium-currents in the vestibular afferent neurons of the rat through a cAMP dependent mechanism.Frontiers in cellular neuroscience · 2014Article
- Discharge regularity in the turtle posterior crista: comparisons between experiment and theory.Journal of neurophysiology · 2013Article
- Hyperpolarization-activated current (I(h)) in vestibular calyx terminals: characterization and role in shaping postsynaptic events.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Afferent innervation patterns in the vestibular periphery are complex, and vestibular afferents show a large variation in their regularity of firing. Calyx fibers terminate on type I vestibular hair cells and have firing characteristics distinct from the bouton fibers that innervate type II hair cells. Whole-cell patch clamp was used to investigate ionic currents that could influence firing patterns in calyx terminals. Underlying K(Ca) conductances have been described in vestibular ganglion cells, but their presence in afferent terminals has not been investigated previously. Apamin, a selective blocker of SK-type calcium-activated K(+) channels, was tested on calyx afferent terminals isolated from gerbil semicircular canals during postnatal days 1-50. Lowering extracellular calcium or application of apamin (20-500 nM) reduced slowly activating outward currents in voltage clamp. Apamin also reduced the action potential afterhyperpolarization (AHP) in whole-cell current clamp, but only after the first two postnatal weeks. K(+) channel expression increased during the first postnatal month, and SK channels were found to contribute to the AHP, which may in turn influence discharge regularity in calyx vestibular afferents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.