ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
N-Acetylcysteine prevents baker's-yeast-induced inflammation and fever.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Efficacy and safety of anti-inflammatory drug-assisted treatment of symptoms in patients with schizophrenia: a meta-analysis.BMC psychiatry · 2026Pooled it
- An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis.Psychological medicine · 2019Pooled it
- Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update.Schizophrenia bulletin · 2014Pooled it
- New Insights into the Role of Glutathione in the Mechanism of Fever.International journal of molecular sciences · 2020Review
- Brain Metabolomics Reveal the Antipyretic Effects of Jinxin Oral Liquid in Young Rats by Using Gas Chromatography⁻Mass Spectrometry.Metabolites · 2019Article
- Metabolomics of the Antipyretic Effects of Bubali Cornu (Water Buffalo Horn) in Rats.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designTo investigate whether N-acetylcysteine (NAC) alters baker's-yeast-induced fever and inflammation. MATERIAL OR SUBJECTS: Male Wistar rats (26-28 days old) injected with baker's yeast (135 mg/kg, intraperitoneal) or prostaglandin E(2) (300 ng/100 μL, intrathecal). TREATMENT: Rats were injected with NAC (500 mg/kg, subcutaneous, or 50 μg/100 μL, intrathecal) 1 h before, or 2 h after, pyrogen injection.
methodsRectal temperature changes induced by baker's yeast, PGE(2) and NAC were followed up over time. Four hours after baker's yeast injection, total leukocytes, protein, interleukin (IL)-1β, tumor necrosis factor (TNF)-α and nonprotein thiol content were assessed in peritoneal lavage and hypothalamus.
resultsSystemic administration of NAC decreased leukocytes, protein, IL-1β and TNF-α levels in peritoneal lavage, and decreased IL-1β levels in the hypothalamus. The central administration of NAC prevented baker's-yeast-induced fever, but did not alter the febrile response elicited by prostaglandin E(2).
conclusionThese results suggest an anti-inflammatory and antipyretic role for NAC in yeast-induced peritonitis.
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