ArticleCirculation. Cardiovascular genetics2012
Relation of lipid gene scores to longitudinal trends in lipid levels and incidence of abnormal lipid levels among individuals of European ancestry: the Atherosclerosis Risk in Communities (ARIC) study.
Article in Circulation. Cardiovascular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Relationship Between Whole Blood Iron Levels and Lipid Profile Parameters in the General Population: Findings from Routine Physical Examination Report.Biological trace element research · 2025Article
- A Nutrigenetic Strategy for Reducing Blood Lipids and Low-Grade Inflammation in Adults with Obesity and Overweight.Nutrients · 2023Article
- Age and Genetic Risk Score and Rates of Blood Lipid Changes in China.JAMA network open · 2023Article
- Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and "Missing" Heritability.Biomedicines · 2021Review
- Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population.PloS one · 2021Article
- Article
- Genetics of Hypertriglyceridemia.Frontiers in endocrinology · 2020Review
- Low Lipid Levels and High Variability are Associated With the Risk of New-Onset Atrial Fibrillation.Journal of the American Heart Association · 2019Article
- Markers of vitamin D metabolism and incidence of clinically diagnosed abdominal aortic aneurysm: The Atherosclerosis Risk in Communities Study.Vascular medicine (London, England) · 2018Article
- Prediction of Blood Lipid Phenotypes Using Obesity-Related Genetic Polymorphisms and Lifestyle Data in Subjects with Excessive Body Weight.International journal of genomics · 2018Article
- From Neighborhood to Genome: Three Decades of Nutrition-Related Research from the Atherosclerosis Risk in Communities Study.Journal of the Academy of Nutrition and Dietetics · 2017Article
- Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.International journal of epidemiology · 2017Article
- Serum vitamin D and change in lipid levels over 5 y: The Atherosclerosis Risk in Communities study.Nutrition (Burbank, Los Angeles County, Calif.) · 2017Article
- Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community.Journal of the American Heart Association · 2017Article
- Increasing insulin resistance accentuates the effect of triglyceride-associated loci on serum triglycerides during 5 years.Journal of lipid research · 2016Article
- Associations of genetic variants for adult lipid levels with lipid levels in children. The Generation R Study.Journal of lipid research · 2016Article
- Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium.PloS one · 2016Article
- Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study.PLoS genetics · 2014Article
- Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls.Annals of the rheumatic diseases · 2014Article
- Sex-specific heritability of spontaneous lipid levels in an extended pedigree of Indian-origin rhesus macaques (Macaca mulatta).PloS one · 2013Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMultiple genetic loci have been associated with blood lipid levels. We tested the hypothesis that persons with an unfavorable lipid gene profile would experience a greater increase in lipid levels and a higher incidence of abnormal lipid levels relative to those with more-favorable lipid gene profiles. METHODS AND
resultsA total of 9328 individuals of European descent (aged 45-64 years) in the ARIC (Atherosclerosis Risk in Communities) study were followed for 9 years. Separate gene scores were created for each lipid phenotype on the basis of 95 loci identified in a published genome-wide association study of >100 000 people of European-descent. Adjusted linear and survival models were used to estimate associations with lipid levels and incidence of lipid-lowering medication or abnormal lipid levels. Age and sex interactions were also explored. The cross-sectional difference (mg/dL) per 1 SD was -1.89 for high-density lipoprotein cholesterol (HDL-C), 9.5 for low-density lipoprotein cholesterol (LDL-C), and 22.8 for triglycerides (P<5×10(-34) for all). Longitudinally, overall triglyceride levels rose over time, and each 1-SD greater triglyceride gene score was associated with an average increase in triglyceride levels of 0.3 mg/dL (P=0.003) over 3 years. The HDL-C, LDL-C, and total cholesterol gene scores were not related to change. All lipid gene scores were positively related to incidence of abnormal lipid levels over follow-up (hazard ratios per SD range, 1.15-1.36).
conclusionsAssociations of genetic variants with lipid levels over time are complex. The triglyceride gene score was positively related to change in triglycerides levels, but similar longitudinal results were not observed for LDL-C or HDL-C levels. Unfavorable gene scores were nevertheless related to higher incidence of abnormal levels.
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