ArticleClinical and experimental medicine2012
Altered IL-10 and TNF-α production in peripheral blood mononuclear cells of systemic lupus erythematosus patients after Toll-like receptor 2, 4, or 9 activation.
Article in Clinical and experimental medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- TLR7 and TLR9 have overlapping but distinct roles in systemic lupus erythematosus and Sjögren's disease.Frontiers in immunology · 2026Review
- Association Between Severity of Leptospirosis and Subsequent Major Autoimmune Diseases: A Nationwide Observational Cohort Study.Frontiers in immunology · 2021Article
- TLR2 Expression on Select Lymphocyte Subsets as a New Marker in Glomerulonephritis.Journal of clinical medicine · 2020Article
- Early echocardiographic detection of left ventricular diastolic dysfunction in patients with systemic lupus erythematosus asymptomatic for cardiovascular disease.Clinical and experimental medicine · 2020Article
- Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal.Annals of the rheumatic diseases · 2019Article
- Relevance of Receptor for Advanced Glycation end Products (RAGE) in Murine Antibody-Mediated Autoimmune Diseases.International journal of molecular sciences · 2019Article
- VIPER regulates naive T cell activation and effector responses: Implication in TLR4 associated acute stage T cell responses.Scientific reports · 2018Article
- Toll-like receptors in lupus nephritis.Journal of biomedical science · 2018Review
- Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata.BBA clinical · 2016Article
- Expression of Toll‑like receptors 3 and 9 in Egyptian systemic lupus erythematosus patients.Zeitschrift fur Rheumatologie · 2016Article
- Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus.Arthritis research & therapy · 2015Article
- The decreased frequency of SIGIRR-positive CD4+ T cells in peripheral blood of patients with SLE and its correlation with disease activity.Molecular biology reports · 2015Article
- TLR2 and TLR4 in autoimmune diseases: a comprehensive review.Clinical reviews in allergy & immunology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptor (TLR) activation and cytokines have been linked to the disease flare of systemic lupus erythematosus (SLE), yet the expression profiles of TLRs and cytokines in response to TLR activation in SLE patients remain unclear. In this study, we evaluated the expression levels of IL-10, TNF-α, interferon-γ (IFN-γ), TLR-2, TLR-4, and TLR-9 in peripheral blood mononuclear cells (PBMCs) from SLE patients and normal controls after PBMCs were stimulated with a TLR-2, TLR-4, or TLR-9 agonist. The expression levels in SLE patient group were statistically compared with those in normal control group. It was found in SLE patients that the IL-10 protein production was down-regulated after the activation of TLR-2, TLR-4, or TLR-9 and that the TNF-α protein production was decreased after the activation of TLR-2 or TLR-9, but not TLR-4. However, the transcript levels of IL-10 and TNF-α as well as the protein and transcript levels of IFN-γ were comparable between SLE and normal control groups. In addition, the TLR-2 transcript levels seem to be diminished after the activation of TLR-2, TLR-4, or TLR-9, but TLR-4 and TLR-9 transcript levels were not altered. The results indicate that the cytokine production from PBMCs in response to TLR activation is dysregulated in SLE patients, supporting the possibility that TLR activation may influence lupus disease activity through regulating cytokine production.
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