ArticlePediatric surgery international2012
Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats.
Article in Pediatric surgery international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 101 citations in OpenAlex.
- Cyanoacrylate Adhesive in Free Gingival Graft Healing: A Digital and Microcirculatory Randomized Clinical Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Trial
- Randomized, Paired-Site Comparison of Autologous Engineered Skin Substitutes and Split-Thickness Skin Graft for Closure of Extensive, Full-Thickness Burns.Journal of burn care & research : official publication of the American Burn AssociationTrial
- Three-dimensional Bovine Collagen-Elastin Matrix in Soft Tissue Reconstruction: No Detectable Bovine DNA After 1 Year.Plastic and reconstructive surgery. Global open · 2026Article
- Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation.Advanced healthcare materials · 2024Review
- Combining bioengineered human skin with bioprinted cartilage for ear reconstruction.Science advances · 2023Article
- A Histological and Clinical Study of MatriDerm® Use in Burn Reconstruction.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study.Life (Basel, Switzerland) · 2023Article
- The LipoDerm Method for Regeneration and Reconstruction in Plastic Surgery: A Technical Experimental Ex Vivo Note.Medical sciences (Basel, Switzerland) · 2023Article
- Treatment of Complex Wounds with NovoSorbJournal of personalized medicine · 2022Article
- Smart 3D Printed Hydrogel Skin Wound Bandages: A Review.Polymers · 2022Review
- Immunohistochemical Analysis of Postburn Scars following Treatment Using Dermal Substitutes.Analytical cellular pathology (Amsterdam) · 2022Article
- [Experimental study on the effect of three-dimensional porous structures on the vascularization rate of artificial dermis].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.Materials science & engineering. R, Reports : a review journal · 2021Article
- A Short History of Skin Grafting in Burns: From the Gold Standard of Autologous Skin Grafting to the Possibilities of Allogeneic Skin Grafting with Immunomodulatory Approaches.Medicina (Kaunas, Lithuania) · 2021Review
- Reconstruction of Full-thickness Soft Tissue Defects with Integra: Risk Factors and Treatment Algorithm.Plastic and reconstructive surgery. Global open · 2020Article
- Advanced Hydrogels as Wound Dressings.Biomolecules · 2020Review
- Down-Regulation of MHC Class I Expression in Human Keratinocytes Using Viral Vectors ContainingInternational journal of molecular sciences · 2019Article
- Processing of collagen based biomaterials and the resulting materials properties.Biomedical engineering online · 2019Review
- Induction of angiogenic and inflammation-associated dermal biomarkers following acute UVB exposure on bio-engineered pigmented dermo-epidermal skin substitutes in vivo.Pediatric surgery international · 2019Article
- Prevascularization of collagen-glycosaminoglycan scaffolds: stromal vascular fraction versus adipose tissue-derived microvascular fragments.Journal of biological engineering · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDermal templates, such as Matriderm® and Integra®, are widely used in plastic and reconstructive surgery, often as two-step procedures. A recent development is the application of thin dermal templates covered with split thickness skin grafts in one-step procedures. In this experimental study, we compare the two thin matrices Matriderm® 1 mm and Integra® Single Layer in a one-step procedure with particular focus on neodermis formation.
methodsMatriderm® 1 mm and Integra® Dermal Regeneration Template-Single Layer (1.3 mm) were compared in a rat model. In three groups of five animals each, a full thickness wound was covered with (a) Matriderm® 1 mm and neonatal rat epidermis, (b) Integra® Single Layer and neonatal rat epidermis, or, (c) neonatal rat epidermis only (control). Histological sections 2 weeks post transplantation were analyzed with regard to take of template and epidermis, neodermal thickness, collagen deposition, vascularization, and inflammatory response.
resultsTake of both templates was complete in all animals. The Matriderm®-based neodermis was thinner but showed a higher cell density than the Integra®-based neodermis. The other parameters were similar in both matrices.
conclusionThe two templates demonstrate a comparable biological behavior early after transplantation. The only difference was found regarding neodermal thickness, probably resulting from faster degradation of Matriderm®. These preliminary data suggest that both dermal templates appear similarly suitable for transplantation in a one-step procedure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.