ReviewChromosoma2012
Rescue of replication failure by Fanconi anaemia proteins.
Review in Chromosoma, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 32 citations in OpenAlex.
- The two sides of chromosomal instability: drivers and brakes in cancer.Signal transduction and targeted therapy · 2024Review
- Fanconi anemia: current insights regarding epidemiology, cancer, and DNA repair.Human genetics · 2022Review
- Review
- Review
- Transcription-mediated replication hindrance: a major driver of genome instability.Genes & development · 2019Review
- Review
- Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.Nucleic acids research · 2017Article
- Rescue from replication stress during mitosis.Cell cycle (Georgetown, Tex.) · 2017Review
- FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells.Scientific reports · 2016Article
- Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.Nucleic acids research · 2016Article
- The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.Molecular cell · 2015Article
- Exploiting replicative stress to treat cancer.Nature reviews. Drug discovery · 2015Review
- Detailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma Cells.PloS one · 2015Article
- Updating the mechanisms of common fragile site instability: how to reconcile the different views?Cellular and molecular life sciences : CMLS · 2014Review
- The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.The Journal of biological chemistry · 2014Article
- Multiple interactions of the intrinsically disordered region between the helicase and nuclease domains of the archaeal Hef protein.The Journal of biological chemistry · 2014Article
- A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy.Oncotarget · 2014Article
- A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.Nucleic acids research · 2014Article
- Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells.Oncoscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal aberrations are often associated with incomplete genome duplication, for instance at common fragile sites, or as a consequence of chemical alterations in the DNA template that block replication forks. Studies of the cancer-prone disease Fanconi anaemia (FA) have provided important insights into the resolution of replication problems. The repair of interstrand DNA crosslinks induced by chemotherapy drugs is coupled with DNA replication and controlled by FA proteins. We discuss here the recent discovery of new FA-associated proteins and the development of new tractable repair systems that have dramatically improved our understanding of crosslink repair. We focus also on how FA proteins protect against replication failure in the context of fragile sites and on the identification of reactive metabolites that account for the development of Fanconi anaemia symptoms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.