Evidence map›Paper›PMID 22057282›Full record

ArticleDigestive diseases and sciences2012

Up-regulated expression of advanced glycation end-products and their receptor in the small intestine and colon of diabetic rats.

Pengmin Chen, Jingbo Zhao, Hans Gregersen

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Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  11. Intestinal parasitic infections and associated risk factors in diabetic patients: a case-control study.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Pengmin ChenMech-Sense, Aalborg Hospital, Sdr Skovvej 15, 9000 Aalborg, Denmark.
Jingbo Zhao
Hans Gregersen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsGastrointestinal disorders and symptoms are common in diabetic patients. Advanced glycation end-products (AGEs) and their receptor (RAGE) have been proposed as an important pathological mechanism underlying diabetic complications, such as diabetic cardiopathy, retinopathy, nephropathy, etc. The aims were to study the distribution of AGE and RAGE in the normal and diabetic small intestine and colon in rats and the possible relationship between AGEs/RAGE and diabetes-induced intestinal structural remodeling.

methodsDiabetic and age-matched normal rats survived for 56 days. The body weight and blood glucose were measured regularly until day 56. Jejunal, ileal, and colonic segments were excised. The wet weight per unit length and the layer thickness were measured. AGE and RAGE were detected by immunohistochemical staining.

resultsThe wet weight per unit length in the three segments and the layer thickness in jejunum and ileum increased in the diabetic rats. The staining density of AGE in diabetic rats was higher in the villi of jejunum and ileum, and in the crypt and circumferential muscle layer of ileum compared to normal rats. The staining intensity of RAGE increased in ganglia, crypt, and brush border of diabetic jejunum and ileum as well as in ganglia of diabetic colon. Positive association was found between the accumulation of AGE and RAGE and the thickness of the different layers.

conclusionsThe expression of AGE and RAGE is up-regulated in the small intestine and colon of diabetic rats. The increased AGE and RAGE levels may contribute to diabetic GI dysfunction.

Indexed as

AnimalsColonDiabetes Mellitus, ExperimentalDisease Models, AnimalGastrointestinal DiseasesGlycation End Products, AdvancedIleumJejunumMaleMuscle, SmoothRatsRats, WistarReceptor for Advanced Glycation End ProductsReceptors, ImmunologicStreptozocinUp-RegulationGlycation End Products, AdvancedReceptor for Advanced Glycation End ProductsReceptors, ImmunologicStreptozocin

Identifiers

PMID22057282

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.