ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Improving taste sensitivity in healthy adults using taste recall training: a randomized controlled trial.Scientific reports · 2022Trial
- Article
- Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023Review
- [Mechanisms and Management of COVID-19-Associated Taste Disorders].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Role of Transient Receptor Potential Vanilloid 1 in Sonic Hedgehog-Dependent Taste Bud Differentiation.Life (Basel, Switzerland) · 2022Article
- Glucagon-like peptide-1, a matter of taste?Reviews in endocrine & metabolic disorders · 2021Review
- N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions.Aging · 2021Article
- Taste Sensitivity of Elderly People Is Associated with Quality of Life and Inadequate Dietary Intake.Nutrients · 2021Article
- Incretins in obesity and diabetes.Annals of the New York Academy of Sciences · 2020Review
- Selective Peripheral Taste Dysfunction in APP/PS1 Mutant Transgenic Mice.Journal of Alzheimer's disease : JAD · 2020Article
- Correlation between Taste Threshold Sensitivity and MMP-9, Salivary Secretion, Blood Pressure, and Blood Glucose Levels in Smoking and Nonsmoking Women.International journal of dentistry · 2020Article
- Article
- Appetite, Metabolism and Hormonal Regulation in Normal Ageing and Dementia.Diseases (Basel, Switzerland) · 2018Review
- Gli3 is a negative regulator of Tas1r3-expressing taste cells.PLoS genetics · 2018Article
- An Update on the Sense of Taste in Chickens: A Better Developed System than Previously Appreciated.Journal of nutrition & food sciences · 2018Article
- Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction.The Journal of biological chemistry · 2017Article
- Article
- Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- AP1 transcription factors are required to maintain the peripheral taste system.Cell death & disease · 2016Article
- The endocrinology of taste receptors.Nature reviews. Endocrinology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Normal aging is a complex process that affects every organ system in the body, including the taste system. Thus, we investigated the effects of the normal aging process on taste bud morphology, function, and taste responsivity in male mice at 2, 10, and 18 months of age. The 18-month-old animals demonstrated a significant reduction in taste bud size and number of taste cells per bud compared with the 2- and 10-month-old animals. The 18-month-old animals exhibited a significant reduction of protein gene product 9.5 and sonic hedgehog immunoreactivity (taste cell markers). The number of taste cells expressing the sweet taste receptor subunit, T1R3, and the sweet taste modulating hormone, glucagon-like peptide-1, were reduced in the 18-month-old mice. Concordant with taste cell alterations, the 18-month-old animals demonstrated reduced sweet taste responsivity compared with the younger animals and the other major taste modalities (salty, sour, and bitter) remained intact.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.