ArticleAnnals of epidemiology2012
Prospective analysis of association between use of statins or other lipid-lowering agents and colorectal cancer risk.
Article in Annals of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Medication use and risk of proximal colon cancer: a systematic review of prospective studies with narrative synthesis and meta-analysis.Cancer causes & control : CCC · 2021Pooled it
- Statins and the risk of colorectal cancer: an updated systematic review and meta-analysis of 40 studies.World journal of gastroenterology · 2014Pooled it
- Association between remnant cholesterol and colorectal cancer risk in Korea: a nationwide population-based study.The Korean journal of internal medicine · 2026Article
- Dose-response effect of statins on colorectal cancer risk in IBD: a nationwide cohort study.BMC cancer · 2026Observational
- The Effect of Statins on Markers of Breast Cancer Proliferation and Apoptosis in Women with In Situ or Early-Stage Invasive Breast Cancer.International journal of molecular sciences · 2024Article
- Integrative genomic and transcriptomic analysis reveals immune subtypes and prognostic markers in ovarian clear cell carcinoma.British journal of cancer · 2022Article
- Effect of Metabolic Syndrome and Individual Components on Colon Cancer Characteristics and Prognosis.Frontiers in oncology · 2021Article
- The association between statins and colorectal cancer stage in the Women's Health Initiative.Molecular and clinical oncology · 2019Article
- Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.Nature communications · 2019Article
- An analysis of the effect of statins on the risk of Non-Hodgkin's Lymphoma in the Women's Health Initiative cohort.Cancer medicine · 2018Article
- An analysis of the association between statin use and risk of endometrial and ovarian cancers in the Women's Health Initiative.Gynecologic oncology · 2018Article
- Statin consumption as a risk factor for developing colorectal cancer: a retrospective case study.World journal of surgical oncology · 2017Article
- Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.Atherosclerosis · 2017Review
- Variability in statin-induced changes in gene expression profiles of pancreatic cancer.Scientific reports · 2017Article
- Reply to Comment on 'Statin use and all-cancer survival: prospective results from the Women's Health Initiative'.British journal of cancer · 2017Article
- Protective Effects of Statins in Cancer: Should They Be Prescribed for High-Risk Patients?Current atherosclerosis reports · 2016Review
- Preoperative serum lipid profile and outcome in nonmetastatic colorectal cancer.Chronic diseases and translational medicine · 2016Article
- Relation of statin use with non-melanoma skin cancer: Prospective results from the Women's Health Initiative.Women's health (London, England) · 2016Article
- Concomitant Statin Use Has a Favorable Effect on Gemcitabine-Erlotinib Combination Chemotherapy for Advanced Pancreatic Cancer.Yonsei medical journal · 2016Article
- Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer.EBioMedicine · 2016Article
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
purposeTo determine whether 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) are associated with a decreased risk of colorectal cancer.
methodsThe population included 159,219 postmenopausal women enrolled in the Women's Health Initiative in which 2000 pathologically confirmed cases of colorectal cancer were identified during an average of 10.7 (S.D. 2.9) years. Information on statins was collected at baseline and years 1, 3, 6, and 9. Self- and interviewer-administered questionnaires were used to collect information on other risk factors. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by the use of Cox proportional hazards regression to evaluate the relationship between statin use and risk. Statistical tests were two-sided.
resultsStatins were used by 12,030 (7.6%) women at baseline. The annualized colorectal cancer rate was 0.13% among users and 0.12% among nonusers. The multivariable adjusted HR for users versus nonusers was 0.99 (95% confidence interval [CI], 0.83-1.20, p = .95), and 0.79 (95% CI, 0.56-1.11) for users of ≥3 years. In the multivariable adjusted time-dependent model, the HR for lovastatin was 0.62 (95% CI, 0.39-0.99). There was no effect of tumor location, stage or grade.
conclusionsThere was a reduction in colorectal cancer risk associated with lovastatin and a nonsignificant association with longer duration of use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.