Evidence map›Paper›PMID 22056371›Full record

ArticleLife sciences2012

Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander.

Surapong Chatpun, Pedro Cabrales

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Surapong ChatpunDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA.
Pedro Cabrales
University of California, San Diego · US

Funding

BIOENGINEERING DESIGN OF ARTIFICIAL BLOODR24HL064395 · NHLBI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI INTAGLIETTA, MARCOS · 2000 to 2004
$5.0M
Bioengineering Design of Artificial BloodR01HL064395 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI INTAGLIETTA, MARCOS · 2007 to 2011
$3.6M
BLOOD FLOW AND RHEOLOGY IN THE VENOUS MICROCIRCULATIONR01HL052684 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CABRALES, PEDRO · 1996 to 2011
$3.3M
TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERSR01HL062354 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI INTAGLIETTA, MARCOS · 2000 to 2009
$2.9M
NHLBI NIH HHS R01 HL052684NHLBI NIH HHS R01 HL062354NHLBI NIH HHS R01 HL064395NHLBI NIH HHS R01-HL52684NHLBI NIH HHS R01-HL62354NHLBI NIH HHS R24 HL064395NHLBI NIH HHS R24-HL64395
6 · The paper itself

Abstract

aimsThis study evaluated the hypothesis that exogenous nitric oxide (NO) supplementation during acute hemodilution with plasma expander (PE) provides beneficial effects on cardiac function. MAIN

methodsAcute hemodilution in golden Syrian hamsters was induced by a 40% of blood volume exchange with dextran 70 kDa. Intravascular NO supplementation after hemodilution was accomplished with a NO donor, diethylenetriamine NONOate (DETA NONOate). The test group was treated with DETA NONOate, while the control group received only vehicle. Left ventricular cardiac function was studied using pressure-volume measurements obtained with a miniaturized conductance catheter. KEY

findingsCardiac output increased to 122±5% and 107±1% of the baseline in the group treated with NO donor and the vehicle group, respectively. Stroke work per stroke volume (SW/SV) after hemodilution reduced to 90% of the baseline and the NO donor significantly reduced SW/SV compared to the vehicle. The minimum rate of pressure change (dP/dt(min)) was significantly lower in animals treated with the NO donor compared to vehicle treated animals. Systemic vascular resistance (SVR) decreased to 62±5% of the baseline in the NO donor group whereas the vehicle group SVR decreased to 83±5% of the baseline. Using intravital microscopy analysis of microvessel in the dorsal skinfold window chamber, we established that the NO donor group induced significant vasodilation compared to the vehicle group. SIGNIFICANCE: NO supplementation in an acute hemodilution with PE has beneficial effects on cardiac performance. However, the NO supplementation effects with a NO donor are dose-independent and short-lasting.

Indexed as

AnimalsBlood VolumeCricetinaeHemodilutionInfusions, Intra-ArterialInfusions, IntravenousMaleMesocricetusNitric OxideNitric Oxide DonorsPlasma SubstitutesVentricular Function, LeftNitric OxideNitric Oxide DonorsPlasma Substitutes

Identifiers

PMID22056371
PMCPMC3246102
OpenAlexW2082153045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.