Evidence map›Paper›PMID 22055570›Full record

ReviewCurrent opinion in microbiology2012

Plasticity in mast cell responses during bacterial infections.

Cheryl Y Chan, Ashley L St John, Soman N Abraham

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Stromal Cell-Mast Cell Communication Orchestrates Anti-Viral Immunity in the Meninges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Mast Cell Biology at Molecular Level: a Comprehensive Review.Clinical reviews in allergy & immunology · 2020
    Review
  9. Mast cells are critical for controlling the bacterial burden and the healing of infected wounds.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. Article
  11. Review
  12. Review
  13. Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017
    Article
  14. Are Mast Cells MASTers in Cancer?Frontiers in immunology · 2017
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cheryl Y ChanDepartment of Pathology, Duke University Medical Center, Durham, NC, USA.
Ashley L St John
Soman N Abraham

Funding

Caveolae Mediated Bacterial Uptake in the Urinary TractR01AI050021 · NIAID · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N · 2001 to 2010
$3.6M
LIGAND RECEPTOR INTERACTIONS IN UTISR37DK050814 · NIDDK · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N · 1999 to 2008
$2.7M
Overcoming Immunosenescence by Nanoparticle-Mediated ActivationR01AI096305 · NIAID · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N, LEONG, KAM W · 2012 to 2016
$1.8M
Modulation of Bladder cAMP to combat UTI'sR01DK077159 · NIDDK · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N · 2007 to 2011
$1.7M
NIAID NIH HHS R01 AI050021NIAID NIH HHS R01 AI096305NIDDK NIH HHS R01 DK077159NIDDK NIH HHS R37 DK050814NIDDK NIH HHS R37 DK50814PHS HHS R01 A135678PHS HHS R01 A150021PHS HHS R21 A1056101
6 · The paper itself

Abstract

Mast cells (MCs) have been implicated in orchestrating the host's early innate immune and adaptive immune responses in several models of acute bacterial infections. Most of this activity results in early clearance of the bacteria and timely resolution of infection. However, during chronic infections because of the prolonged nature of MC-bacterial interactions, the role of the MC in determining the fate of infection is markedly more complex. Depending on the nature of the pathogen, severity of infection, and its association with a preexisting inflammatory disease, MCs may promote rather than contain chronic infections and exacerbate their pathological sequellae.

Indexed as

AnimalsBacteriaBacterial InfectionsHumansMast CellsMiceModels, Biological

Identifiers

PMID22055570
PMCPMC4476652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.