Evidence map›Paper›PMID 22055494›Full record

ReviewCurrent opinion in chemical biology2011

Quantum dots find their stride in single molecule tracking.

Marcel P Bruchez

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Quantum Dots for Improved Single-Molecule Localization Microscopy.The journal of physical chemistry. B · 2021
    Article
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  18. Towards physiological complexity with in vitro single-molecule biophysics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Marcel P BruchezCarnegie Mellon University, Department of Chemistry, Pittsburgh, PA 15213, USA. bruchez@cmu.edu

Funding

FLUORESCENT PROBES &IMAGING FOR NETWORKS &PATHWAY(RMI)U54RR022241 · NCRR · MELLON PITTS CORPORATION (MPC CORP) · PI WAGGONER, ALAN S. · 2005 to 2011
$19.9M
Bright Blinking Probes for Fast Multicolor Superresolution Imaging in Live CellsR01GM086237 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BRUCHEZ, MARCEL P · 2009 to 2010
$347k
NCRR NIH HHS 7U54RR022241NCRR NIH HHS U54 RR022241NIGMS NIH HHS 5R01GM086237NIGMS NIH HHS R01 GM086237
6 · The paper itself

Abstract

Thirteen years after the demonstration of quantum dots as biological imaging agents, and nine years after the initial commercial introduction of bioconjugated quantum dots, the brightness and photostability of the quantum dots has enabled a range of investigations using single molecule tracking. These materials are being routinely utilized by a number of groups to track the dynamics of single molecules in reconstituted biophysical systems and on living cells, and are especially powerful for investigations of single molecules over long timescales with short exposure times and high pointing accuracy. New approaches are emerging where the quantum dots are used as 'hard-sphere' probes for intracellular compartments. Innovations in quantum dot surface modification are poised to substantially expand the utility of these materials.

Indexed as

Quantum DotsCell Membrane PermeabilityDNAFluorescent DyesMicroscopy, FluorescenceNanotechnologyProteinsStaining and LabelingDNAFluorescent DyesProteins

Identifiers

PMID22055494
PMCPMC3237804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.