ReviewCurrent opinion in neurobiology2012
Protein SUMOylation in spine structure and function.
Review in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Dysregulation of protein SUMOylation networks in Huntington's disease R6/2 mouse striatum.Brain : a journal of neurology · 2025Article
- Article
- Proteomic Identification of an Endogenous Synaptic SUMOylome in the Developing Rat Brain.Frontiers in molecular neuroscience · 2021Article
- Opioid and chemokine regulation of cortical synaptodendritic damage in HIV-associated neurocognitive disorders.Brain research · 2019Review
- Variation in expression of small ubiquitin-like modifiers in injured sciatic nerve of mice.Neural regeneration research · 2019Article
- Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function.Archives of pharmacal research · 2019Review
- Regulation of axon repulsion by MAX-1 SUMOylation and AP-3.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Hypothermia inhibits the proliferation of bone marrow-derived mesenchymal stem cells and increases tolerance to hypoxia by enhancing SUMOylation.International journal of molecular medicine · 2017Article
- Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.Biological psychiatry · 2017Article
- Commentary: Analysis of SUMO1-conjugation at synapses.Frontiers in cellular neuroscience · 2017Article
- Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.Nature communications · 2016Article
- Biological findings from the PheWAS catalog: focus on connective tissue-related disorders (pelvic floor dysfunction, abdominal hernia, varicose veins and hemorrhoids).Human genetics · 2016Article
- SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.Nature communications · 2015Article
- SUMO1 Affects Synaptic Function, Spine Density and Memory.Scientific reports · 2015Article
- Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.Physiological reviews · 2014Review
- Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.Journal of psychiatry & neuroscience : JPN · 2014Article
- Proteomics of protein post-translational modifications implicated in neurodegeneration.Translational neurodegeneration · 2014Review
- Tomosyn interacts with the SUMO E3 ligase PIASγ.PloS one · 2014Article
- Receptor trafficking and the regulation of synaptic plasticity by SUMO.Neuromolecular medicine · 2013Review
- Estradiol potentiates 8-OH-DPAT-induced sumoylation of 5-HT₁A receptor: characterization and subcellular distribution of sumoylated 5-HT₁A receptors.Psychoneuroendocrinology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The active regulation of spine structure and function is of fundamental importance for information storage in the brain. Many proteins involved in spine development and activity-dependent remodelling are potential or validated substrates for modification by the Small Ubiquitin-like Modifier (SUMO). The functional consequences of neuronal protein SUMOylation appear diverse and, in many cases, have not yet been determined. However, for several proteins SUMOylation has been shown to be a key regulator, which has a profound impact on spine dynamics and protein trafficking and function. Here we provide an overview of neuronal SUMOylation and discuss how greater understanding of this relatively recently discovered posttranslational modification will provide insight into the complexity of protein interactions that control synaptic activity and dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.