Evidence map›Paper›PMID 22054733›Full record

ReviewHematology/oncology clinics of North America2011

Chronic myelogenous leukemia: role of stem cell transplant in the imatinib era.

Nitin Jain, Koen van Besien

Open access · greenAbstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nitin JainSection of Hematology/Oncology, Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Koen van Besien
University of Chicago · US

Funding

Immunologic and pharmacologic studies in allotransplantK24CA116471 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI VAN BESIEN, KOEN WALTER · 2007 to 2011
$882k
NCI NIH HHS K24 CA116471
6 · The paper itself

Abstract

In the pre-tyrosine kinase (TKI) era, allogeneic stem cell transplant (allo-SCT) was the front-line treatment of choice for young patients with chronic myelogenous leukemia (CML). Today, imatinib is well established as front-line therapy for CML, with excellent long-term outcomes. This has changed the role of allo-SCT and the number of patients undergoing allo-SCT has declined dramatically. Allo-SCT is currently recommended for patients in accelerated/blast phase disease, those who have failed a second-generation TKI and those with TKI-resistant mutations such as T315I. The role of allo-SCT in the management of CML will require continual reappraisal as medical therapies continue to evolve.

Indexed as

Stem Cell TransplantationBenzamidesDrug Resistance, NeoplasmHumansImatinib MesylateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMutationPiperazinesProtein Kinase InhibitorsPyrimidinesTransplantation, HomologousBenzamidesImatinib MesylatePiperazinesProtein Kinase InhibitorsPyrimidines

Identifiers

PMID22054733
PMCPMC3246008
OpenAlexW2074651560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.