ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2011
Risk of prostate cancer associated with benign prostate disease: a primary care case-control study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Systematic review of clinical features of suspected prostate cancer in primary care.Canadian family physician Medecin de famille canadien · 2015Pooled it
- Knowledge and practice of prostate cancer screening among general practitioners in Malaysia: a cross-sectional study.BMJ open · 2016Article
- Cancer and primary care: the clinical and research agenda.The British journal of general practice : the journal of the Royal College of General Practitioners · 2011Article
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Authors and funding
4 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundBenign diseases of the prostate are common in the general male population, and prostate cancer is the most common cancer in men. Uncertainty as to the nature of the association between benign and malignant disease is a source of concern for patients and clinicians.
aimTo determine the likelihood of men with benign prostate disease developing prostate cancer compared with men without disease.
designIncident matched case-control study.
methodAll incident cases of prostate cancer (n = 984) were identified in a nationally representative community-based population, and each was matched by age with two controls with no prostate cancer (n = 1968). Participants' records of the previous 5 years were searched for diagnoses of benign prostate disease. Analyses investigated an a priori hypothesis that clinicians may record disease as benign until proven to be malignant, causing misleading significant associations between benign and malignant diagnoses.
resultsThere was a significant association between a diagnosis of prostate cancer and a benign diagnosis at any time in the previous 5 years: odds ratio (OR) 1.57 (95% confidence interval [CI] = 1.32 to 1.88). However, there was no significant association when benign diagnoses within 6 months and within 12 months of cancer diagnoses were excluded: OR 1.19 (95% CI = 0.97 to 1.46) and OR 1.00 (95% CI = 0.79 to 1.27) respectively.
conclusionFindings from this study suggest that unless prostate cancer is detected within 6 months, men diagnosed for the first time with benign disease are at no greater risk of prostate cancer than those with no recorded prostate disease.
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