ArticleMolecular oral microbiology2011
Filifactor alocis interactions with gingival epithelial cells.
Article in Molecular oral microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 69 citations in OpenAlex.
- Functional Characterization of a Putative Sortase FA1364 inInternational journal of molecular sciences · 2026Article
- Increased bacterial load ofFrontiers in oral health · 2025Article
- Possible immunomodulatory role of Filifactor alocis through beta-defensin 2 in gingival keratinocytes.Clinical oral investigations · 2024Article
- Dying for a cause: The pathogenic manipulation of cell death and efferocytic pathways.Molecular oral microbiology · 2024Review
- Association ofDentistry journal · 2024Article
- Whole Genome Sequencing and Phenotypic Analysis of Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- Characterization of FA1654: A putative DPS protein in Filifactor alocis.Molecular oral microbiology · 2023Article
- Periodontal disease severity is associated to pathogenic consortia comprising putative and candidate periodontal pathogens.Journal of applied oral science : revista FOB · 2023Article
- Oral and gastric microbiome in relation to gastric intestinal metaplasia.International journal of cancer · 2022Article
- Microbiome differences in periodontal, peri-implant, and healthy sites: a cross-sectional pilot study.Clinical oral investigations · 2022Article
- Host and bacterial factors linking periodontitis and rheumatoid arthritis.Frontiers in immunology · 2022Review
- Multi-omics analysis reveals the host-microbe interactions in aged rhesus macaques.Frontiers in microbiology · 2022Article
- Article
- Esophageal microbiome in active eosinophilic esophagitis and changes induced by different therapies.Scientific reports · 2021Article
- Comparison of three qPCR-based commercial tests for detection of periodontal pathogens.Scientific reports · 2021Article
- Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues.International journal of molecular sciences · 2021Article
- Dysbiosis of salivary microbiome and cytokines influence oral squamous cell carcinoma through inflammation.Archives of microbiology · 2021Article
- Role of Superoxide Reductase FA796 in Oxidative Stress Resistance in Filifactor alocis.Scientific reports · 2020Article
- Regulation of matrix metalloproteinase-1 by Filifactor alocis in human gingival and monocytic cells.Clinical oral investigations · 2020Article
- Microbial and metabolomic analysis of gingival crevicular fluid in general chronic periodontitis patients: lessons for a predictive, preventive, and personalized medical approach.The EPMA journal · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
An association between the gram-positive anaerobe Filifactor alocis and periodontal disease has recently emerged; however, possible pathogenic mechanisms have not been investigated. In this study we examined the responses of primary cultures of gingival epithelial cells (GECs) to infection with F. alocis. Secretion of the pro-inflammatory cytokines interleukin-1β, interleukin-6 and tumor necrosis factor-α from GECs was stimulated by F. alocis infection. F. alocis also induced apoptosis in GECs through pathways that involved caspase-3 but not caspase-9. Apoptosis was coincident with inhibition of mitogen-activated protein kinase kinase (MEK) activation. These results show that F. alocis has characteristics in common with established periodontal pathogens and has the potential to contribute to periodontal tissue destruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.