ArticleBMC microbiology2011
Oral Candida albicans isolates from HIV-positive individuals have similar in vitro biofilm-forming ability and pathogenicity as invasive Candida isolates.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
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- Characteristics of Candida albicans Derived From HIV-Positive Individuals With Oral Candidiasis: Genotyping, Phenotypic Variation, Antifungal Susceptibility, and Biofilm Formation.Journal of clinical laboratory analysis · 2024Article
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- Overview on the Infections Related to RarePathogens (Basel, Switzerland) · 2022Review
- Ozonated oil is effective at killing Candida species and Streptococcus mutans biofilm-derived cells under aerobic and microaerobic conditions.Medical mycology · 2022Article
- Antimicrobial Photodynamic Therapy Mediated by Fotenticine and Methylene Blue on Planktonic Growth, Biofilms, and Burn Infections ofAntibiotics (Basel, Switzerland) · 2022Article
- A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.Nature communications · 2021Article
- Virulence of ClinicalPathogens (Basel, Switzerland) · 2021Article
- Candida albicans Mrv8, is involved in epithelial damage and biofilm formation.FEMS yeast research · 2020Article
- Microbial Contamination and Disinfection of Sport Mouthguard: In Vitro Study.Current microbiology · 2020Article
- Article
- Standardization ofJournal of fungi (Basel, Switzerland) · 2018Review
- Galleria mellonella as a host model to study Candida glabrata virulence and antifungal efficacy.Virulence · 2017Article
- Usefulness of the Non-conventional Caenorhabditis elegans Model to Assess Candida Virulence.Mycopathologia · 2017Article
- Temporal Profile of Biofilm Formation, Gene Expression and Virulence Analysis in Candida albicans Strains.Mycopathologia · 2017Article
- Article
- Streptococcus mutans Can Modulate Biofilm Formation and Attenuate the Virulence of Candida albicans.PloS one · 2016Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCandida can cause mucocutaneous and/or systemic infections in hospitalized and immunosuppressed patients. Most individuals are colonized by Candida spp. as part of the oral flora and the intestinal tract. We compared oral and systemic isolates for the capacity to form biofilm in an in vitro biofilm model and pathogenicity in the Galleria mellonella infection model. The oral Candida strains were isolated from the HIV patients and included species of C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. krusei, C. norvegensis, and C. dubliniensis. The systemic strains were isolated from patients with invasive candidiasis and included species of C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. lusitaniae, and C. kefyr. For each of the acquired strains, biofilm formation was evaluated on standardized samples of silicone pads and acrylic resin. We assessed the pathogenicity of the strains by infecting G. mellonella animals with Candida strains and observing survival.
resultsThe biofilm formation and pathogenicity in Galleria was similar between oral and systemic isolates. The quantity of biofilm formed and the virulence in G. mellonella were different for each of the species studied. On silicone pads, C. albicans and C. dubliniensis produced more biofilm (1.12 to 6.61 mg) than the other species (0.25 to 3.66 mg). However, all Candida species produced a similar biofilm on acrylic resin, material used in dental prostheses. C. albicans, C. dubliniensis, C. tropicalis, and C. parapsilosis were the most virulent species in G. mellonella with 100% of mortality, followed by C. lusitaniae (87%), C. novergensis (37%), C. krusei (25%), C. glabrata (20%), and C. kefyr (12%).
conclusionsWe found that on silicone pads as well as in the Galleria model, biofilm formation and virulence depends on the Candida species. Importantly, for C. albicans the pathogenicity of oral Candida isolates was similar to systemic Candida isolates, suggesting that Candida isolates have similar biofilm-forming ability and virulence regardless of the infection site from which it was isolated.
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