ArticleEpigenetics & chromatin2011
Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.
Article in Epigenetics & chromatin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- NIPSNAP1 directs dual mechanisms to restrain senescence in cancer cells.Journal of translational medicine · 2023Article
- The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.Cell reports · 2022Article
- Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage.PLoS genetics · 2021Article
- Genome-Wide Analysis of c-MYC-Regulated mRNAs and miRNAs and c-MYC DNA-Binding by Next-Generation Sequencing.Methods in molecular biology (Clifton, N.J.) · 2021Article
- MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity.Oncogene · 2020Article
- Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis.Nature cell biology · 2020Article
- TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.Molecular cell · 2019Article
- Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential.Scientific reports · 2017Article
- Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells.Frontiers in cell and developmental biology · 2017Review
- CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells.PloS one · 2017Article
- Expression of Ribosomal RNA and Protein Genes in Human Embryonic Stem Cells Is Associated With the Activating H3K4me3 Histone Mark.Journal of cellular physiology · 2016Article
- Article
- Multi-layered global gene regulation in mouse embryonic stem cells.Cellular and molecular life sciences : CMLS · 2015Review
- A cell engineering strategy to enhance the safety of stem cell therapies.Cell reports · 2014Article
- Nac1 interacts with the POZ-domain transcription factor, Miz1.Bioscience reports · 2014Article
- Article
- Roles for MYC in the establishment and maintenance of pluripotency.Cold Spring Harbor perspectives in medicine · 2013Review
- Control of vertebrate development by MYC.Cold Spring Harbor perspectives in medicine · 2013Review
- Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain.Biochemical and biophysical research communications · 2013Article
- Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.Nature immunology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important open topic.
resultsTo test the hypothesis that the zinc finger protein Miz-1 plays a central role, in the present work we conducted chromatin immunoprecipitation/microarray (ChIP-chip) analysis of Myc and Miz-1 in human ES cells, finding homeobox (Hox) genes as the most significant functional class of Miz-1 direct targets. Miz-1 differentiation-associated target genes specifically lack acetylated lysine 9 and trimethylated lysine 4 of histone H3 (AcH3K9 and H3K4me3) 9 histone marks, consistent with a repressed transcriptional state. Almost 30% of Miz-1 targets are also bound by Myc and these cobound genes are mostly factors that promote differentiation including Hox genes. Knockdown of Myc increased expression of differentiation genes directly bound by Myc and Miz-1, while a subset of the same genes is downregulated by Miz-1 loss-of-function. Myc and Miz-1 proteins interact with each other and associate with several corepressor factors in ES cells, suggesting a mechanism of repression of differentiation genes.
conclusionsTaken together our data indicate that Miz-1 and Myc maintain human ES cell pluripotency by coordinately suppressing differentiation genes, particularly Hox genes. These data also support a new model of how Myc and Miz-1 function on chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.