ArticleCell communication and signaling : CCS2011
The next evolutionary synthesis: from Lamarck and Darwin to genomic variation and systems biology.
Article in Cell communication and signaling : CCS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Whole genome regulatory effect ofmBio · 2024Article
- Thomas S. Kuhn: key to a better understanding of the extended evolutionary synthesis.Theory in biosciences = Theorie in den Biowissenschaften · 2024Article
- Reimagining an immunological dogma.Nature immunology · 2021Article
- From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering.Advances in experimental medicine and biology · 2017Review
- The Lamarckian chicken and the Darwinian egg.Biology direct · 2015Article
- Guest list or black list: heritable small RNAs as immunogenic memories.Trends in cell biology · 2014Review
- Cooperation between phenotypic plasticity and genetic mutations can account for the cumulative selection in evolution.Biophysics (Nagoya-shi, Japan) · 2014Article
- The soft genome.WormArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary synthesis, the standard 20th century view of how evolutionary change occurs, is based on selection, heritable phenotypic variation and a very simple view of genes. It is therefore unable to incorporate two key aspects of modern molecular knowledge: first is the richness of genomic variation, so much more complicated than simple mutation, and second is the opaque relationship between the genotype and its resulting phenotype. Two new and important books shed some light on how we should view evolutionary change now. "Evolution: a view from the 21st century" by J.A. Shapiro (2011, FT Press Science, New Jersey, USA. pp. 246) examines the richness of genomic variation and its implications. "Transformations of Lamarckism: from Subtle Fluids to Molecular Biology" edited by S.B. Gissis & E. Jablonka (2011, MIT Press, Cambridge, USA. pp. 457) includes some 40 papers that anyone with an interest in the history of evolutionary thought and the relationship between the environment and the genome will want to read. This review discusses both books within the context of contemporary evolutionary thinking and points out that neither really comes to terms with today's key systems-biology question: how does mutation-induced variation in a molecular network generate variation in the resulting phenotype?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.