ArticlePloS one2011
Activity-dependent changes in cholinergic innervation of the mouse olfactory bulb.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 31 citations in OpenAlex.
- Calretinin-Expressing Neurons in the Basal Forebrain Specifically Contact Granule Cells in the Olfactory Bulb and Modulate Odor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Olfactory Optogenetics: Light Illuminates the Chemical Sensing Mechanisms of Biological Olfactory Systems.Biosensors · 2021Review
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- The relationship between olfaction and cognitive function in the elderly.The journal of physiological sciences : JPS · 2020Article
- Input dependent modulation of olfactory bulb activity by HDB GABAergic projections.Scientific reports · 2020Article
- Developmental Remodeling of Thalamic Interneurons Requires Retinal Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Basal forebrain GABAergic innervation of olfactory bulb periglomerular interneurons.The Journal of physiology · 2019Article
- A dominant role for the beta 4 nicotinic receptor subunit in nicotinic modulation of glomerular microcircuits in the mouse olfactory bulb.Journal of neurophysiology · 2018Article
- Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb.Nature communications · 2017Article
- The Pig Olfactory Brain: A Primer.Chemical senses · 2016Article
- Increased olfactory bulb acetylcholine bi-directionally modulates glomerular odor sensitivity.Scientific reports · 2016Article
- Movement of magnetic nanoparticles in brain tissue: mechanisms and impact on normal neuronal function.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- Differential Muscarinic Modulation in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Signaling between periglomerular cells reveals a bimodal role for GABA in modulating glomerular microcircuitry in the olfactory bulb.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Synaptic connectivity of the cholinergic axons in the olfactory bulb of the cynomolgus monkey.Frontiers in neuroanatomy · 2015Article
- Special function of nestin(+) neurons in the medial septum-diagonal band of Broca in adult rats.Neural regeneration research · 2014Article
- Paying attention to smell: cholinergic signaling in the olfactory bulb.Frontiers in synaptic neuroscience · 2014Review
- The mouse olfactory peduncle. 3. Development of neurons, glia, and centrifugal afferents.Frontiers in neuroanatomy · 2014Article
- Nicotinic receptors modulate olfactory bulb external tufted cells via an excitation-dependent inhibitory mechanism.Journal of neurophysiology · 2013Article
- Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.Chemical senses · 2013Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The interplay between olfactory activity and cholinergic modulation remains to be fully understood. This report examines the pattern of cholinergic innervation throughout the murine main olfactory bulb across different developmental stages and in naris-occluded animals. To visualize the pattern of cholinergic innervation, we used a transgenic mouse model, which expresses a fusion of the microtubule-associated protein, tau, with green fluorescence protein (GFP) under the control of the choline acetyltransferase (ChAT) promoter. This tau-GFP fusion product allows for a remarkably vivid and clear visualization of cholinergic innervation in the main olfactory bulb (MOB). Interestingly, we find an uneven distribution of GFP label in the adult glomerular layer (GL), where anterior, medial, and lateral glomerular regions of the bulb receive relatively heavier cholinergic innervation than other regions. In contrast to previous reports, we find a marked change in the pattern of cholinergic innervation to the GL following unilateral naris occlusion between the ipsilateral and contralateral bulbs in adult animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.