ArticleChemistry of materials : a publication of the American Chemical Society2011
Structurally Diverse Nitric Oxide-Releasing Poly(propylene Imine) Dendrimers.
Article in Chemistry of materials : a publication of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy.Pharmacological reviews · 2022Review
- Recent Developments in Nitric Oxide Donors and Delivery for Antimicrobial and Anti-Biofilm Applications.Molecules (Basel, Switzerland) · 2022Review
- The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications.Biochemical pharmacology · 2020Review
- Nitric Oxide (NO)-Releasing Macromolecules: Rational Design and Biomedical Applications.Frontiers in chemistry · 2019Review
- Nitric oxide-releasing hyperbranched polyaminoglycosides for antibacterial therapy.ACS applied bio materials · 2018Article
- Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications.Advanced healthcare materials · 2018Review
- Antibacterial Activity of Nitric Oxide-Releasing Hyperbranched Polyamidoamines.Bioconjugate chemistry · 2018Article
- Article
- Nitric oxide in paediatric respiratory disorders: novel interventions to address associated vascular phenomena?Therapeutic advances in cardiovascular disease · 2016Review
- Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release.ACS applied materials & interfaces · 2016Article
- Anti-biofilm action of nitric oxide-releasing alkyl-modified poly(amidoamine) dendrimers against Streptococcus mutans.Acta biomaterialia · 2016Article
- Antibacterial Action of Nitric Oxide-Releasing Chitosan Oligosaccharides against Pseudomonas aeruginosa under Aerobic and Anaerobic Conditions.Antimicrobial agents and chemotherapy · 2015Article
- Kinetic-dependent Killing of Oral Pathogens with Nitric Oxide.Journal of dental research · 2015Article
- Nitric oxide-releasing poly(lactic-co-glycolic acid)-polyethylenimine nanoparticles for prolonged nitric oxide release, antibacterial efficacy, and in vivo wound healing activity.International journal of nanomedicine · 2015Article
- S-Nitrosothiol-modified nitric oxide-releasing chitosan oligosaccharides as antibacterial agents.Acta biomaterialia · 2015Article
- Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents.Biomaterials · 2014Article
- Fabrication of nitric oxide-releasing porous polyurethane membranes-coated needle-type implantable glucose biosensors.Analytical chemistry · 2013Article
- Nitric oxide-releasing amphiphilic poly(amidoamine) (PAMAM) dendrimers as antibacterial agents.Biomacromolecules · 2013Article
- Nitric oxide-releasing silica nanoparticle-doped polyurethane electrospun fibers.ACS applied materials & interfaces · 2013Article
- Nitric oxide-releasing xerogels synthesized from N-diazeniumdiolate-modified silane precursors.ACS applied materials & interfaces · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Structurally diverse secondary amine-functionalized poly(propylene imine) (PPI) dendrimers capable of tunable nitric oxide (NO) release were synthesized in a straightforward, one-step manner using ring-opening or conjugate-addition reactions with propylene oxide (PO), styrene oxide (SO), acrylonitrile (ACN), poly(ethylene glycol) methyl ether acrylate (average Mn = 480) (PEG) or 1,2-epoxy-9-decene (ED). N-Diazeniumdiolate nitric oxide donors were formed on the resulting secondary amine-functionalized G2-G5 PPI dendrimers by reaction with NO gas in basic solution. The NO storage and release kinetics for the resulting dendritic scaffolds were diverse (0.9-3.8 μmol NO/mg totals and 0.3 to 4.9 h half lives), illustrating the importance of the exterior chemical modification (e.g., steric environments, hydrophobicity, etc.) on diazeniumdiolate stability/decomposition. Tunable NO release was demonstrated by combining two donor systems on the exterior of one macromolecular scaffold. Additionally, a mathematical model was developed that allows for the simulation of dual NO release kinetics using the NO release data from the two single NO donor systems. The approaches described herein extend the range and scope of NO-releasing macromolecular scaffolds by unlocking a series of materials for use as dopants in biomedical polymers or stand-alone therapeutics depending on the exterior modification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.