ArticleTetrahedron letters2011
First total synthesis of (+)-Vedelianin, a potent antiproliferative agent.
Article in Tetrahedron letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Article
- Substitution of a triazole for the central olefin in biologically active stilbenes.Bioorganic & medicinal chemistry letters · 2022Article
- Synthesis of a Coumarin-Based Analogue of Schweinfurthin F.The Journal of organic chemistry · 2021Article
- UHPLC-HESI-OT-MS-MS Biomolecules Profiling, Antioxidant and Antibacterial Activity of the "Orange-Yellow Resin" fromAntioxidants (Basel, Switzerland) · 2020Article
- Schweinfurthins A-Q: isolation, synthesis, and biochemical properties.RSC advances · 2018Review
- Synthesis of amide isosteres of schweinfurthin-based stilbenes.Bioorganic & medicinal chemistry · 2017Article
- Synthesis and structure activity relationships of schweinfurthin indoles.Bioorganic & medicinal chemistry · 2014Article
- Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists.Journal of natural products · 2014Article
- Relevance of the C-5 position to schweinfurthin induced cytotoxicity.Bioorganic & medicinal chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S, 3R, 4aR, 9aR)-isomer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.