ArticleNucleic acids research2012
Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis.PLoS biology · 2021Article
- Past, present, and perspectives of protein N-terminal methylation.Current opinion in chemical biology · 2021Review
- An Improved Top-Down Mass Spectrometry Characterization ofJournal of the American Society for Mass Spectrometry · 2021Article
- Histone N-alpha terminal modifications: genome regulation at the tip of the tail.Epigenetics & chromatin · 2020Review
- Chemical Biology of Protein N-Terminal Methyltransferases.Chembiochem : a European journal of chemical biology · 2019Review
- An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.Communications biology · 2018Article
- Molecular basis for histone N-terminal methylation by NRMT1.Genes & development · 2015Article
- Structural basis for substrate recognition by the human N-terminal methyltransferase 1.Genes & development · 2015Article
- Kinetic mechanism of protein N-terminal methyltransferase 1.The Journal of biological chemistry · 2015Article
- Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors.Organic & biomolecular chemistry · 2015Article
- New roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease.Protein science : a publication of the Protein Society · 2014Review
- Identification of novel α-n-methylation of CENP-B that regulates its binding to the centromeric DNA.Journal of proteome research · 2013Article
- Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics.International journal of molecular sciences · 2013Article
- Catalytic promiscuity of a bacterial α-N-methyltransferase.FEBS letters · 2012Article
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Authors and funding
6 authors.
Funding
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Abstract
Histone post-translational modifications play an important role in regulating chromatin structure and gene expression in vivo. Extensive studies investigated the post-translational modifications of the core histones H3 and H4 or the linker histone H1. Much less is known on the regulation of H2A and H2B modifications. Here, we show that a major modification of H2B in Drosophila melanogaster is the methylation of the N-terminal proline, which increases during fly development. Experiments performed in cultured cells revealed higher levels of H2B methylation when cells are dense, regardless of their cell cycle distribution. We identified dNTMT (CG1675) as the enzyme responsible for H2B methylation. We also found that the level of N-terminal methylation is regulated by dART8, an arginine methyltransferase that physically interacts with dNTMT and asymmetrically methylates H3R2. Our results demonstrate the existence of a complex containing two methyltransferases enzymes, which negatively influence each other's activity.
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