ArticleArteriosclerosis, thrombosis, and vascular biology2012
Determinants of microvascular network topologies in implanted neovasculatures.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Adipose-derived microvascular fragments: Functional microtissue units driving vascular integration and multidimensional tissue regeneration.Regenerative therapy · 2026Review
- Bioprinted vascular tissue: Assessing functions from cellular, tissue to organ levels.Materials today. Bio · 2023Review
- Dynamic Biophysical Cues Near the Tip Cell Microenvironment Provide Distinct Guidance Signals to Angiogenic Neovessels.Annals of biomedical engineering · 2023Article
- Vertebrate and Invertebrate Animal and New In Vitro Models for StudyingPathogens (Basel, Switzerland) · 2023Review
- Vascularized Tissue Organoids.Bioengineering (Basel, Switzerland) · 2023Review
- Mechanical regulation of the early stages of angiogenesis.Journal of the Royal Society, Interface · 2022Review
- Hybprinting for musculoskeletal tissue engineering.iScience · 2022Review
- From arteries to capillaries: approaches to engineering human vasculature.Advanced functional materials · 2020Article
- Stromal Cells Promote Neovascular Invasion Across Tissue Interfaces.Frontiers in physiology · 2020Article
- Type I Diabetes Delays Perfusion and Engraftment of 3D Constructs by Impinging on Angiogenesis; Which can be Rescued by Hepatocyte Growth Factor Supplementation.Cellular and molecular bioengineering · 2019Article
- Decorin-supplemented collagen hydrogels for the co-delivery of bone morphogenetic protein-2 and microvascular fragments to a composite bone-muscle injury model with impaired vascularization.Acta biomaterialia · 2019Article
- Vascularization of Engineered Spatially Patterned Myocardial Tissue Derived From Human Pluripotent Stem CellsFrontiers in bioengineering and biotechnology · 2019Article
- Vasculogenic and angiogenic potential of adipose stromal vascular fraction cell populations in vitro.In vitro cellular & developmental biology. Animal · 2018Article
- Additive Manufacturing of Vascular Grafts and Vascularized Tissue Constructs.Tissue engineering. Part B, Reviews · 2017Review
- Article
- Current status of three-dimensional printing inks for soft tissue regeneration.Tissue engineering and regenerative medicine · 2016Review
- A coupled model of neovessel growth and matrix mechanics describes and predicts angiogenesis in vitro.Biomechanics and modeling in mechanobiology · 2015Article
- In Silico Investigation of Angiogenesis with Growth and Stress Generation Coupled to Local Extracellular Matrix Density.Annals of biomedical engineering · 2015Article
- Large-scale time series microscopy of neovessel growth during angiogenesis.Angiogenesis · 2015Article
- Making microvascular networks work: angiogenesis, remodeling, and pruning.Physiology (Bethesda, Md.) · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveDuring neovascularization, the end result is a new functional microcirculation composed of a network of mature microvessels with specific topologies. Although much is known concerning the mechanisms underlying the initiation of angiogenesis, it remains unclear how the final architecture of microcirculatory beds is regulated. To begin to address this, we determined the impact of angiogenic neovessel prepatterning on the final microvascular network topology using a model of implant neovascularization. METHODS AND
resultsWe used 3D direct-write bioprinting or physical constraints in a manner permitting postangiogenesis vascular remodeling and adaptation to pattern angiogenic microvascular precursors (neovessels formed from isolated microvessel segments) in 3D collagen gels before implantation and subsequent network formation. Neovasculatures prepatterned into parallel arrays formed functional networks after 4 weeks postimplantation but lost the prepatterned architecture. However, maintenance of uniaxial physical constraints during postangiogenesis remodeling of the implanted neovasculatures produced networks with aligned microvessels, as well as an altered proportional distribution of arterioles, capillaries, and venules.
conclusionsHere we show that network topology resulting from implanted microvessel precursors is independent from prepatterning of precursors but can be influenced by a patterning stimulus involving tissue deformation during postangiogenesis remodeling and maturation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.