Evidence map›Paper›PMID 22053042›Full record

ArticleScience (New York, N.Y.)2011

The cell biology of synaptic plasticity.

Victoria M Ho, Ji-Ann Lee, Kelsey C Martin

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. An integratediScience · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Turning garbage into gold: Autophagy in synaptic function.Current opinion in neurobiology · 2025
    Review
  20. Soft Artificial Synapse Electronics.Research (Washington, D.C.) · 2025
    Review

109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Victoria M HoInterdepartmental Program in Neurosciences, University of California-Los Angeles (UCLA), BSRB 390B, 615 Charles E. Young Drive South, Los Angeles, CA 90095-1737, USA.
Ji-Ann Lee
Kelsey C Martin

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Synapse to Nuclear Signaling During Long-Lasting Neuronal PlasticityR01MH077022 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2007 to 2017
$3.1M
Localized mRNAs in Synaptic PlasticityR01NS045324 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2003 to 2013
$2.8M
Training Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4M
The Ubiquitin Proteasome Pathway &Synaptic PlasticityR21MH069645 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2004 to 2005
$276k
NIGMS NIH HHS T32 GM008042NIMH NIH HHS R01 MH077022NIMH NIH HHS R21 MH069645NIMH NIH HHS T32 MH073526NINDS NIH HHS R01 NS045324
6 · The paper itself

Abstract

Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.

Indexed as

AnimalsGene Expression RegulationHippocampusHumansLearningMemoryNeurogliaNeuronal PlasticityNeuronsSynapsesSynaptic Transmission

Identifiers

PMID22053042
PMCPMC3286636

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.