ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2012
Large body size and sedentary lifestyle during childhood and early adulthood and esophageal squamous cell carcinoma in a high-risk population.
Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis.Journal of sport and health science · 2021Pooled it
- Physical activity is associated with reduced risk of esophageal cancer, particularly esophageal adenocarcinoma: a systematic review and meta-analysis.BMC gastroenterology · 2014Pooled it
- The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis.European journal of epidemiology · 2014Pooled it
- Pooled it
- Body size and occupational physical activity during the life course and gastrointestinal cancers.American journal of epidemiology · 2025Article
- Investigating the obesity trend of overweight and obese people with pictograms among Iranian adults.Journal of diabetes and metabolic disorders · 2025Article
- The Effect of Opioid Use on Esophageal Cancer: A Systematic Review and Meta-analysis.Addiction & health · 2025Review
- Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990-2019.Thoracic cancer · 2024Observational
- Updated epidemiology of gastrointestinal cancers in East Asia.Nature reviews. Gastroenterology & hepatology · 2023Review
- Aberrations in ion channels interacting with lipid metabolism and epithelial-mesenchymal transition in esophageal squamous cell carcinoma.Frontiers in molecular biosciences · 2023Article
- Pictogram Is a Valid Instrument to Classify At-Risk Adult Population Based on Abdominal Obesity: Results from Pars Cohort Study.Archives of Iranian medicine · 2022Article
- Adult height, body mass index change, and body shape change in relation to esophageal squamous cell carcinoma risk: A population-based case-control study in China.Cancer medicine · 2019Article
- Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: A prospective cohort study within UK Biobank.United European gastroenterology journal · 2018Article
- Epidemiology of Esophageal Squamous Cell Carcinoma.Gastroenterology · 2018Review
- Sitting time and occupational and recreational physical activity in relation to the risk of esophageal squamous cell carcinoma.OncoTargets and therapy · 2017Article
- A prospective cohort study of body size and risk of head and neck cancers in the NIH-AARP diet and health study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Impact of body size and physical activity during adolescence and adult life on overall and cause-specific mortality in a large cohort study from Iran.European journal of epidemiology · 2014Article
- Cooking methods and esophageal squamous cell carcinoma in high-risk areas of Iran.Nutrition and cancer · 2014Article
- Socioeconomic status and esophageal squamous cell carcinoma risk in Kashmir, India.Cancer science · 2013Article
- Physical activity and sedentary behavior in relation to esophageal and gastric cancers in the NIH-AARP cohort.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundLittle is known about the association of obesity and physical activity at young ages with subsequent risk of esophageal squamous cell carcinoma (ESCC). PATIENTS AND
methodsBetween 2003 and 2007, we conducted a case-control study in a high-risk population in northeastern Iran. Three hundred ESCC cases and 571 matched controls were recruited. Each individual was shown a standard pictogram, to report body size at ages 15 and 30. Demographic and health-related information, including physical activity at these ages was also collected.
resultsIn the fully adjusted models, very obese body size (last two pictograms) at age 15 [odds ratio (OR) 3.2, 95% confidence interval (CI) 1.3-7.7] and age 30 (OR 3.1; 95% CI 1.1-8.5) were associated with ESCC in women, but not in men. Sedentary work at age 15 (OR 3.3, 95% CI 1.3-8.3) and 30 (OR 18.2, 95% CI 3.9-86.2) were also associated with ESCC risk in women only. The increased risk in women at age 15 remained high after later reduction in body size, while women who became very obese only at age 30 did not show a significantly increased risk.
conclusionThese results highlight the importance of early lifestyle modifications in the context of cancer prevention, particularly in women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.