ArticleJournal of lipid research2012
Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases.
Article in Journal of lipid research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.Human molecular genetics · 2015Trial
- LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD.Journal of lipid research · 2026Article
- Genome-wide association study of somatic GATA1s mutations in newborns with Down syndrome.Blood advances · 2025Article
- Polysorbates degrading enzymes in biotherapeutics - a current status and future perspectives.Frontiers in bioengineering and biotechnology · 2024Review
- The evolution of small molecule enzyme activators.RSC medicinal chemistry · 2023Review
- Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity.Journal of molecular endocrinology · 2023Article
- Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors.European journal of human genetics : EJHG · 2023Article
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- Expansion of the Strigolactone Profluorescent Probes Repertory: The Right Probe for the Right Application.Frontiers in plant science · 2022Article
- Deglycase-activity oriented screening to identify DJ-1 inhibitors.RSC medicinal chemistry · 2021Article
- Discovery of small-molecule enzyme activators by activity-based protein profiling.Nature chemical biology · 2020Article
- Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae.PloS one · 2020Article
- Non-alcoholic fatty liver disease--a chronic disease of the 21Journal of biomedical research · 2018Article
- Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones.Communications biology · 2018Review
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- A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors.Nature communications · 2017Article
- Crystal structure of Pelagibacterium halotolerans PE8: New insight into its substrate-binding pattern.Scientific reports · 2017Article
- Protein palmitoylation: Palmitoyltransferases and their specificity.Experimental biology and medicine (Maywood, N.J.) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequence homology indicates the existence of three human cytosolic acyl protein thioesterases, including APT1 that is known to depalmitoylate H- and N-Ras. One of them is the lysophospholipase-like 1 (LYPLAL1) protein that on the one hand is predicted to be closely related to APT1 but on the other hand might also function as a potential triacylglycerol lipase involved in obesity. However, its role remained unclear. The 1.7 Å crystal structure of LYPLAL1 reveals a fold very similar to APT1, as expected, but features a shape of the active site that precludes binding of long-chain substrates. Biochemical data demonstrate that LYPLAL1 exhibits neither phospholipase nor triacylglycerol lipase activity, but rather accepts short-chain substrates. Furthermore, extensive screening efforts using chemical array technique revealed a first small molecule inhibitor of LYPLAL1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.