ArticleAmerican journal of respiratory cell and molecular biology2012
Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring.
Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Prenatal Exposure toEnvironmental health perspectives · 2019Article
- Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: Evidence for a reelin-related pathogenic pathway induced by interleukin-6.Brain, behavior, and immunity · 2019Article
- Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice.Particle and fibre toxicology · 2018Article
- In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood.Journal of the American Heart Association · 2017Article
- Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits.Particle and fibre toxicology · 2016Article
- From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity.Preventive medicine · 2015Review
- Environmental Pollution and the Developing Lung.Clinical pulmonary medicine · 2015Article
- Retraction: Maternal diesel inhalation increases airway hyperreactivity in ozone-exposed offspring.American journal of respiratory cell and molecular biology · 2015Article
- Developmental Programming: Priming Disease Susceptibility for Subsequent Generations.Current epidemiology reports · 2015Article
- Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?Clinical epigenetics · 2015Article
- A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust.The Journal of allergy and clinical immunology · 2014Article
- Assessing the impact of race, social factors and air pollution on birth outcomes: a population-based study.Environmental health : a global access science source · 2014Article
- Article
- In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice.Particle and fibre toxicology · 2013Article
- Perinatal factors in neonatal and pediatric lung diseases.Expert review of respiratory medicine · 2013Article
- Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice.Environmental health perspectives · 2013Article
- Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses.PloS one · 2013Article
- Traffic-related air pollution and brain development.AIMS environmental scienceArticle
- Proximity to roadways and pregnancy outcomes.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
- Retraction · 2015-04-01Concerns/Issues about Data · Error in Data · Investigation by Company/Institution · Results Not Reproducible · Unreliable Results and/or Conclusions · · EN Potts aka EN Potts-Kant;
- Commented on by
- Retracted
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Air pollutant exposure is linked with childhood asthma incidence and exacerbations, and maternal exposure to airborne pollutants during pregnancy increases airway hyperreactivity (AHR) in offspring. To determine if exposure to diesel exhaust (DE) during pregnancy worsened postnatal ozone-induced AHR, timed pregnant C57BL/6 mice were exposed to DE (0.5 or 2.0 mg/m(3)) 4 hours daily from Gestation Day 9-17, or received twice-weekly oropharyngeal aspirations of the collected DE particles (DEPs). Placentas and fetal lungs were harvested on Gestation Day 18 for cytokine analysis. In other litters, pups born to dams exposed to air or DE, or to dams treated with aspirated diesel particles, were exposed to filtered air or 1 ppm ozone beginning the day after birth, for 3 hours per day, 3 days per week for 4 weeks. Additional pups were monitored after a 4-week recovery period. Diesel inhalation or aspiration during pregnancy increased levels of placental and fetal lung cytokines. There were no significant effects on airway leukocytes, but prenatal diesel augmented ozone-induced elevations of bronchoalveolar lavage cytokines at 4 weeks. Mice born to the high-concentration diesel-exposed dams had worse ozone-induced AHR, which persisted in the 4-week recovery animals. Prenatal diesel exposure combined with postnatal ozone exposure also worsened secondary alveolar crest development. We conclude that maternal inhalation of DE in pregnancy provokes a fetal inflammatory response that, combined with postnatal ozone exposure, impairs alveolar development, and causes a more severe and long-lasting AHR to ozone exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.