ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2012
Viscoelastic properties of human cortical bone tissue depend on gender and elastic modulus.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 76 citations in OpenAlex.
- Viscoelastic Hydrogels Governed by Molecular Interactions and Mechanochemical Effects.Polymers · 2026Review
- Laser Remelting of Biocompatible Ti-Based Glass-Forming Alloys: Microstructure, Mechanical Properties, and Cytotoxicity.Materials (Basel, Switzerland) · 2025Article
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- Beyond bone volume: Understanding tissue-level quality in healing of maxillary vs. femoral defects.Acta biomaterialia · 2024Article
- Cortical and trabecular mechanical properties in the femoral neck vary differently with changes in bone mineral density.JBMR plus · 2024Article
- Dynamic Hydrogels with Viscoelasticity and Tunable Stiffness for the Regulation of Cell Behavior and Fate.Materials (Basel, Switzerland) · 2023Review
- Effects of different preservation on the mechanical properties of cortical bone under quasi-static and dynamic compression.Frontiers in bioengineering and biotechnology · 2023Article
- Bioactive, Degradable and Tough Hybrids Through Calcium and Phosphate Incorporation.Frontiers in materials · 2022Article
- Article
- Three-dimensional finite element analysis of the effect of alveolar cleft bone graft on the maxillofacial biomechanical stabilities of unilateral complete cleft lip and palate.Biomedical engineering online · 2022Article
- Bone fragility: conceptual framework, therapeutic implications, and COVID-19-related issues.Therapeutic advances in musculoskeletal disease · 2022Review
- Molecular origin of viscoelasticity in mineralized collagen fibrils.Biomaterials science · 2021Article
- Embracing Mechanobiology in Next Generation Organ-On-A-Chip Models of Bone Metastasis.Frontiers in medical technology · 2021Review
- An efficient and accurate method for modeling nonlinear fractional viscoelastic biomaterials.Computer methods in applied mechanics and engineering · 2020Article
- Scaffolds and coatings for bone regeneration.Journal of materials science. Materials in medicine · 2020Review
- The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral cores.Osteoarthritis and cartilage · 2019Article
- The relationship of whole human vertebral body creep to geometric, microstructural, and material properties.Journal of biomechanics · 2018Article
- Sideways fall-induced impact force and its effect on hip fracture risk: a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk.Current osteoporosis reports · 2016Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bone exhibits rate-dependent failure behavior, suggesting that viscoelasticity is a factor in the damage and fracture of bone. Microdamage initiates at scales below the macroscopic porosity in bone, and, as such, is affected by the intrinsic viscoelasticity of the bone tissue. The viscoelasticity of the bone tissue can be measured by nanoindentation and recording the creep behavior at constant load. The viscoelastic properties have been used to assess differences in tissue behavior with respect to fracture healing, aging, and mouse strains. In this study, we compared the viscoelastic behavior of human cortical bone between genders by using nanoindentation at a fixed load of 10 mN to measure the creep time constant. Bones from females had a significantly greater time constant, indicating slower creep and relaxation, than bones from males. The creep time constants decreased with increasing tissue modulus. The mineralization, collagen content, and collagen cross-link density, which were bulk measurements, were analyzed to determine if the differences in viscoelastic behavior were explained by compositional differences in the bone. However, none of the parameters differed between genders, nor were they correlated to the viscoelastic time constant. As such, the difference must depend on other matrix proteins that we did not assess or differences in the microstructural organization. This is one of the only intrinsic bone material properties that has been found to differ between males and females, and it may be important for assessing differences in fracture risk, since crack propagation is generally sensitive to viscoelastic properties.
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Registered trials
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