Evidence map›Paper›PMID 22052672›Full record

ArticleArthritis care & research2012

Determinants of discordance in patients' and physicians' rating of rheumatoid arthritis disease activity.

Nasim A Khan, Horace J Spencer, Esam Abda, Amita Aggarwal, Rieke Alten, Codrina Ancuta, Daina Andersone, Martin Bergman, Jurgen Craig-Muller, Jacqueline Detert and 14 more

Abstract readComparative Study
In one paragraph

Article in Arthritis care & research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 1 synthesis or guideline pooled it.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nasim A KhanUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA. nakhan@uams.edu
Horace J Spencer
Esam Abda
Amita Aggarwal
Rieke Alten
Codrina Ancuta
Daina Andersone
Martin Bergman
Jurgen Craig-Muller
Jacqueline Detert
Lia Georgescu
Laure Gossec
Hisham Hamoud
Johannes W G Jacobs
Ieda Maria Magalhaes Laurindo
Maria Majdan
Antonio Naranjo
Sapan Pandya
Christof Pohl
Georg Schett
Zahraa I Selim
Sergio Toloza
Hisahi Yamanaka
Tuulikki Sokka

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR029884 · NCRR · UNIV OF ARKANSAS FOR MED SCIS · PI LOWERY, CURTIS L · 2009 to 2011
$11.4M
NCRR NIH HHS 1UL1RR029884NCRR NIH HHS UL1 RR029884
6 · The paper itself

Abstract

objectiveTo assess the determinants of patients' (PTGL) and physicians' (MDGL) global assessment of rheumatoid arthritis (RA) activity and factors associated with discordance among them.

methodsA total of 7,028 patients in the Quantitative Standard Monitoring of Patients with RA study had PTGL and MDGL assessed at the same clinic visit on a 0-10-cm visual analog scale (VAS). Three patient groups were defined: concordant rating group (PTGL and MDGL within ±2 cm), higher patient rating group (PTGL exceeding MDGL by >2 cm), and lower patient rating group (PTGL less than MDGL by >2 cm). Multivariable regression analysis was used to identify determinants of PTGL and MDGL and their discordance.

resultsThe mean ± SD VAS scores for PTGL and MDGL were 4.01 ± 2.70 and 2.91 ± 2.37, respectively. Pain was overwhelmingly the single most important determinant of PTGL, followed by fatigue. In contrast, MDGL was most influenced by swollen joint count (SJC), followed by erythrocyte sedimentation rate (ESR) and tender joint count (TJC). A total of 4,454 (63.4%), 2,106 (30%), and 468 (6.6%) patients were in the concordant, higher, and lower patient rating groups, respectively. Odds of higher patient rating increased with higher pain, fatigue, psychological distress, age, and morning stiffness, and decreased with higher SJC, TJC, and ESR. Lower patient rating odds increased with higher SJC, TJC, and ESR, and decreased with lower fatigue levels.

conclusionNearly 36% of patients had discordance in RA activity assessment from their physicians. Sensitivity to the "disease experience" of patients, particularly pain and fatigue, is warranted for effective care of RA.

Indexed as

Arthritis, RheumatoidAttitude of Health PersonnelAttitude to HealthPhysician-Patient RelationsSelf-AssessmentArthralgiaFatigueFemaleHealth StatusHumansMaleMiddle AgedPain MeasurementReproducibility of ResultsSeverity of Illness Index

Identifiers

PMID22052672
PMCPMC3703925

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.