ReviewPrion
Modeling Huntington disease in yeast: perspectives and future directions.
Review in Prion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Yeast as a Model for Human Disease.International journal of molecular sciences · 2026Review
- Vitamin B3 Biotech · 2023Article
- Validation of the Pathogenic Effect ofInternational journal of molecular sciences · 2022Article
- Review
- Forced association of SARS-CoV-2 proteins with the yeast proteome perturb vesicle trafficking.Microbial cell (Graz, Austria) · 2021Article
- Huntingtin Polyglutamine Fragments Are a Substrate for Hsp104 in Saccharomyces cerevisiae.Molecular and cellular biology · 2021Article
- NADFrontiers in molecular biosciences · 2021Review
- The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.Biomolecules · 2020Article
- Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals.Biomedicines · 2020Review
- The huntingtin inclusion is a dynamic phase-separated compartment.Life science alliance · 2019Article
- Manganese-induced cellular disturbance in the baker's yeast, Saccharomyces cerevisiae with putative implications in neuronal dysfunction.Scientific reports · 2019Article
- Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington's Disease.Plant physiology · 2019Article
- RNA Aptamers Rescue Mitochondrial Dysfunction in a Yeast Model of Huntington's Disease.Molecular therapy. Nucleic acids · 2018Article
- Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.Scientific reports · 2018Article
- A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.Molecular cell · 2018Article
- A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease.Frontiers in molecular neuroscience · 2018Review
- Studying Huntington's Disease in Yeast: From Mechanisms to Pharmacological Approaches.Frontiers in molecular neuroscience · 2018Review
- Polyglutamine toxicity assays highlight the advantages of mScarlet for imaging inF1000Research · 2018Article
- Combined tRNA modification defects impair protein homeostasis and synthesis of the yeast prion protein Rnq1.Prion · 2017Article
- Article
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Authors and funding
2 authors.
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Abstract
Yeast have been extensively used to model aspects of protein folding diseases, yielding novel mechanistic insights and identifying promising candidate therapeutic targets. In particular, the neurodegenerative disorder Huntington disease (HD), which is caused by the abnormal expansion of a polyglutamine tract in the huntingtin (htt) protein, has been widely studied in yeast. This work has led to the identification of several promising therapeutic targets and compounds that have been validated in mammalian cells, Drosophila and rodent models of HD. Here we discuss the development of yeast models of mutant htt toxicity and misfolding, as well as the mechanistic insights gleaned from this simple model. The role of yeast prions in the toxicity/misfolding of mutant htt is also highlighted. Furthermore, we provide an overview of the application of HD yeast models in both genetic and chemical screens, and the fruitful results obtained from these approaches. Finally, we discuss the future of yeast in neurodegenerative research, in the context of HD and other diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.