ArticleCancer biology & therapy2011
Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis.
Article in Cancer biology & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- The effects of coagulation factors and their inhibitors on proliferation and migration in colorectal cancer.Cancer medicine · 2023Article
- Targeting Protein Synthesis in Colorectal Cancer.Cancers · 2020Review
- Tumor necrosis factor-related apoptosis-inducing ligand inhibits the growth and aggressiveness of colon carcinoma via the exogenous apoptosis signaling pathway.Experimental and therapeutic medicine · 2019Article
- Crosstalk between TF/FVIIa and EGFR signaling in colorectal cancer cells.Cancer biology & therapy · 2019Article
- Physiological Perspective on Therapies of Lymphatic Vessels.Advances in wound care · 2018Review
- Thromboembolism in Patients with Bladder Cancer: Incidence, Risk Factors and Prevention.Bladder cancer (Amsterdam, Netherlands) · 2018Review
- Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy.Seminars in cancer biology · 2015Review
- Tissue factor is strongly expressed in pericarcinomatous tissue in patients with laryngeal carcinoma.International journal of clinical and experimental pathology · 2015Article
- Targeting cell death signaling in colorectal cancer: current strategies and future perspectives.World journal of gastroenterology · 2014Review
- MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion.Molecular and cellular biochemistry · 2013Article
- Article
- Do circulating tumor cells play a role in coagulation and thrombosis?Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue factor (TF) is a significant risk factor for hepatic metastasis in patients with colorectal cancer (CRC). However, the mechanism by which TF promotes hepatic metastasis in CRC remains elusive. In this study, we first confirmed that TF expression was significantly correlated with lymph node metastasis, hepatic metastasis and TNM staging in clinical CRC samples, and found that TF expression in colon cancer cell lines was correlated with the invasion ability. Next, by employing TF-overexpressing LOVO cell line as a model we demonstrated that lentivirus mediated knockdown of TF suppressed the migration and invasion of LOVO cells in vitro, and hepatic metastasis of colorectal cancer in nude mice orthotopic model. Mechanistically, we found that TF knockdown decreases colony formation ability and induced autophagy and apoptosis of LOVO cells, and this was at least partly mediated by the activation of unfolded protein response/PERK signaling. In conclusion, our data provide new insight into hepatic metastasis of CRC. Agents targeting TF should be developed as adjuvant therapeutics for CRC metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.